Preliminary clinical findings on NEUMUNE as a potential treatment for acute radiation syndrome

@article{Stickney2010PreliminaryCF,
  title={Preliminary clinical findings on NEUMUNE as a potential treatment for acute radiation syndrome},
  author={Dwight R. Stickney and Jessie R. Groothuis and Clarence N. Ahlem and Michael R. Kennedy and B Miller and Nanette Onizuka-Handa and Karen M Schlangen and Daniel A. Destiche and Christopher L Reading and Armando Garsd and James M. Frincke},
  journal={Journal of Radiological Protection},
  year={2010},
  volume={30},
  pages={687 - 698}
}
5-androstenediol (5-AED) has been advanced as a possible countermeasure for treating the haematological component of acute radiation syndrome (ARS). It has been used in animal models to stimulate both innate and adaptive immunity and treat infection and radiation-induced immune suppression. We here report on the safety, tolerability and haematologic activity of 5-AED in four double-blinded, randomized, placebo-controlled studies on healthy adults including elderly subjects. A 5-AED injectable… 

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HE2100 is characterized as a most potent novel agent to promote stem cell reconstitution and multilineage myelopoiesis after cytoreductive radiation exposure, resulting in enhanced reticulocyte, neutrophil and platelet recovery and profoundly decreased needs for transfusions and antibiotic treatment.

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