Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients.

@article{Sonis2010PreliminaryCO,
  title={Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients.},
  author={Stephen T. Sonis and Nathaniel Simon Treister and Sant P. Chawla and George Demetri and Frank J Haluska},
  journal={Cancer},
  year={2010},
  volume={116 1},
  pages={210-5}
}
BACKGROUND Mammalian target of rapamycin (mTOR) inhibitors may have efficacy as an intervention for advanced malignancies. Oral ulceration (OU), reported as mucositis, has been a dose-limiting toxicity for this new class of agents. An analysis of the appearance, course, and toxicity associations of mTOR inhibitor-associated stomatitis (mIAS) demonstrated that the condition is distinct from conventional mucositis (CM) and more closely resembles aphthous stomatitis. METHODS Safety data from 78… CONTINUE READING
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