Preliminary brain autopsy findings in progredient Rett syndrome.

  title={Preliminary brain autopsy findings in progredient Rett syndrome.},
  author={Peter Franz Riederer and Madeleine Weiser and Ildiko Wichart and Bernard Schmidt and W R Killian and A. Rett},
  journal={American journal of medical genetics. Supplement},
Postmortem human brain analyses have been performed to further evaluate pathogenetic aspects of the Rett syndrome. While there are no significant abnormalities with respect to amino acid concentrations in putamen, caudate nucleus, red nucleus and thalamus, the concentration of kynurenine is increased in putamen, caudate nucleus, gl. pallidus, raphe and amygdaloid n. In contrast, serotonin and its metabolite 5-hydroxyindole acetic acid are below normal levels. D2-receptor number is decreased and… CONTINUE READING
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