Preliminary assessment of zolpidem pharmacokinetics in pediatric burn patients.

  title={Preliminary assessment of zolpidem pharmacokinetics in pediatric burn patients.},
  author={Chris R Stockmann and Catherine M T Sherwin and Whitney Buterbaugh and Michael M G Spigarelli and Michele M. Gottschlich and Daniel P Healy and Richard J. Kagan},
  journal={Therapeutic drug monitoring},
  volume={36 3},
PURPOSE Severely burned patients frequently experience sleep fragmentation and insomnia. This study evaluated the population pharmacokinetics of the sleep-enhancing agent zolpidem among burned children. METHODS Zolpidem was administered according to the following age-based dosing schedule: 2.5 mg per dose for 2-4 year olds, 5.0 mg per dose for 5-10 year olds, and 10 mg per dose for older than 10 years. Serum samples were collected before and 1, 2, 4, 5, 6, and 8 hours after dosing. The… CONTINUE READING
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