Preliminary activation of lymphocytes with mitogen as the condition for manifestation of ability of Fab-fragments of normal IgG to inhibit lymphocyte transformation

Abstract

Inhibition of blast-transformation of human lymphocytes, induced by phytohemagglutinin (PHA), with the aid of F(ab′)2-fragment of rabbit IgG was studied. Preincubation of lymphocytes with F(ab′)2-fragments for 24 h at 37 and 4°C followed by change of medium and the addition of PHA did not affect the intensity of blast transformation. However, the F(ab′)2… (More)
DOI: 10.1007/BF00833980

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