Preliminary Study of a Pregnanolone Emulsion (KABI 2213) for I.V. Induction of General Anaesthesia

@article{Gutsche1992PreliminarySO,
  title={Preliminary Study of a Pregnanolone Emulsion (KABI 2213) for I.V. Induction of General Anaesthesia},
  author={B. Gutsche and T. Cheek and H. J. Gray and B. Holt and D. Whitaker and P. Eadsforth},
  journal={Survey of Anesthesiology},
  year={1992},
  volume={36},
  pages={343}
}
After a single 1 mg/kg induction dose, response to the commands to open the eyes and to lift the head required 17.7 sec and 20.2 sec, respectively. This is more than twice the time required to recover from a single dose of 2–2.5 mg/kg of propofol. Hence the drug will not be particularly useful in the outpatient who requires general anesthesia, despite the fact induction and emergence are generally pleasant. Even if preg-nanolone has all the other desirable attributes of propofol, without rapid… Expand
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