Preliminary Study of a Pregnanolone Emulsion (KABI 2213) for I.V. Induction of General Anaesthesia

  title={Preliminary Study of a Pregnanolone Emulsion (KABI 2213) for I.V. Induction of General Anaesthesia},
  author={B. Gutsche and T. Cheek and H. J. Gray and B. Holt and D. Whitaker and P. Eadsforth},
  journal={Survey of Anesthesiology},
After a single 1 mg/kg induction dose, response to the commands to open the eyes and to lift the head required 17.7 sec and 20.2 sec, respectively. This is more than twice the time required to recover from a single dose of 2–2.5 mg/kg of propofol. Hence the drug will not be particularly useful in the outpatient who requires general anesthesia, despite the fact induction and emergence are generally pleasant. Even if preg-nanolone has all the other desirable attributes of propofol, without rapid… Expand
Eltanolone as an Alternative to Propofol for Ambulatory Anesthesia
Eltanolone is an investigational steroid anesthetic that causes less pain on injection and less cardiovascular depression than propofol (the most widely used intravenous anesthetic in the outpatient setting). Expand
4 New intravenous induction agents
Thiopentone is absolutely contra-indicated in patients allergic to barbiturates, in patients with acute intermittent porphyria and variegate porphyrm, and in patients where venous access cannot be established. Expand
Comparison of eltanolone and propofol in anesthesia for termination of pregnancy.
Recovery from anesthesia is more rapid from propofol as compared to eltanolone anesthesia, and both clinical and psychomotor recovery returned to baseline more slowly after elTanolone than after prop ofol. Expand
Pharmacokinetics and pharmacodynamics of eltanolone (pregnanolone), a new steroid intravenous anaesthetic, in humans
Eltanolone has a favourable pharmacokinetic profile with relatively rapid half–lives, large distribution volumes and rapid total body clearance and was found to produce smooth and reliable induction of anaesthesia with only minor cardiorespiratory changes and without pain on injection. Expand
Newiv induction anaesthetics
  • D. Morison
  • Medicine
  • Canadian journal of anaesthesia = Journal canadien d'anesthesie
  • 1993
The history of intravenous (iv) anaesthetic induction agents almost mirrors that of the 50 years of the Canadian Anaesthetists' Society and the recent introduction of propofol has provided competition for thiopentone as the standard /v induction agent. Expand
Ventilatory effects of eltanolone during induction of anaesthesia: comparison with propofol and thiopentone.
Eltanolone caused significantly less apnoea than prop ofol (incidence 57% vs 100%) and less reduction in ventilation than propofol (median maximum decrease 4.8 vs 7.8 litre min-1), but the differences between eltanolone and thiopentone were smaller and generally not significant. Expand
Eltanolone for induction of anaesthesia and to supplement nitrous oxide for minor gynaecological surgery
We have used eltanolone to induce anaesthesia and by intermittent injection to supplement nitrous oxide during maintenance in 50 patients undergoing minor gynaecological surgery; opioids were notExpand
A comparison of eltanolone and propofol anaesthesia for minor gynaecological surgery.
It is concluded that eltanolone anaesthesia is associated with a greater haemodynamic stability than propofol anaesthesia but that early recovery occurs more slowly. Expand
Pharmacokinetic-Pharmacodynamic Modeling of the New Steroid Hypnotic Eltanolone in Healthy Volunteers
Eltanolone is a new potent steroid-type hypnotic agent with rapid elimination characteristics that prolongs recovery if larger-than-necessary doses are used to induce anesthesia rapidly and might complicate administration of eltanolone if it is used as a component of a complete intravenous anesthesia regimen. Expand
Pharmacokinetics of eltanolone following bolus injection and constant rate infusion
The pharmacokinetics of eltanolone appear to be linear over the dosage range studied with the exception of t1/2β which was longer after the infusion (significant) and the volume of central compartment which was lower after infusion (not significant). Expand