• Medicine
  • Published 2017

Preliminary Results from Accelerate, an International, Web-Based, Natural History Registry of Castleman Disease

@inproceedings{Fajgenbaum2017PreliminaryRF,
  title={Preliminary Results from Accelerate, an International, Web-Based, Natural History Registry of Castleman Disease},
  author={David C Fajgenbaum and Sheila K. Pierson and Dustin Shilling and C Gardner and Amy Y. Liu and Jasira Ziglar and Shawnee Bernstein and Sarah Mann and Jeremy Zuckerberg and Martin Lukac and Raj Jayanthan and Mary Guilfoyle and Craig L. Tendler and Jason R Ruth and Thomas S Uldrick and Frits van Rhee},
  year={2017}
}
Introduction: Castleman disease (CD) describes a heterogeneous group of disorders that share characteristic histopathological lymph node features. Unicentric CD (UCD) involves localized lymphadenopathy whereas multicentric CD (MCD) involves generalized lymphadenopathy, cytokine-driven systemic inflammatory symptoms, and life-threatening multiple organ system dysfunction. Uncontrolled Human Herpesvirus 8 (HHV-8) infection causes approximately half of MCD cases (HHV-8-associated MCD). The… CONTINUE READING

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