Preliminary Case-control Study to Evaluate Diagnostic Values of C-Reactive Protein and Erythrocyte Sedimentation Rate in Differentiating Active Crohn’s Disease From Intestinal Lymphoma, Intestinal Tuberculosis and Behcet’s Syndrome

@article{Liu2013PreliminaryCS,
  title={Preliminary Case-control Study to Evaluate Diagnostic Values of C-Reactive Protein and Erythrocyte Sedimentation Rate in Differentiating Active Crohn’s Disease From Intestinal Lymphoma, Intestinal Tuberculosis and Behcet’s Syndrome},
  author={Song Liu and Jianan Ren and Qiuyuan Xia and Xiuwen Wu and Gang Han and Huajian Ren and Dongsheng Yan and Gefei Wang and Guosheng Gu and Jie-shou Li},
  journal={The American Journal of the Medical Sciences},
  year={2013},
  volume={346},
  pages={467–472}
}
Background:There are few evidences of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cell (WBC) in differentiating active Crohn’s disease (CD) from intestinal lymphoma (IL), intestinal tuberculosis (ITB) and Behcet’s syndrome (BD). This study is designed to investigate potential differential capacity of the 3 biomarkers between these disorders. Methods:A hospital-based case-control study was performed. A total of 29 active CD, 25 IL, 30 ITB and 17 BD patients… 
Role of Combined Blood Neutrophil- Lymphocyte Ratio and C-reactive Protein in Diagnosis of Spontaneous Bacterial Peritonitis
TLDR
The results revealed that there was statistical significant difference between two studied groups regarding WBCs, neutrophils, hemoglobin and CRP, and it was concluded that Combined NLR andCRP could be used as a novel, simple, lowcost, non-invasive test for SBP diagnosis.
Possible Role of Regulatory B Cells in Different Behçet’s Disease Phenotypes and Therapies: First Report from Egypt
TLDR
This study supports the role of B cells in BD pathogenesis and strongly suggests a possible role for Bregs in the resolution of different BD manifestations.
Correlation of IL-8 and C - Reactive Protein Serum Levels with the Severity of Inflammatory Acne Vulgaris: A Comparative Study
TLDR
In IAV, IL-8 and CRP are proportionally correlating to the severity of inflammatory acne vulgaris, and blocking IL- 8 and CPR production may hold promise therapy in limiting the deleterious effects of IL-9 and CPR mediated inflammatory response.
The Diagnostic Value of IL8 Compared with CRP , ESR in the Detection of Bacterial Infections in Pediatric Oncology Patients with Febrile Neutropenia
TLDR
IL-8 is the most useful marker for the early detection of bacterial infections , compared with CRP , ESR and this marker can be a useful tool for evaluating patients who are at the high risk of infection and candidate for intravenous antibiotics.
Evaluation of the usefulness of C-reactive protein as a marker of urinary tract infection and its response to treatment in persons with spinal cord injury.
TLDR
CRP can be used as a surrogate marker for detecting urinary tract infection in spinal cord injury patients in addition to clinical symptoms and after excluding all other causes of inflammation and infection.
Protozoa Infections and Celiac disease: Relationship and hematological study among children under five years
TLDR
It is found that most of neutrophilia and eosinophilia cases were in E. histolytica and G. lamblia, and Hemoglobin concentration show a significant decrease in patients with diarrhea.
Investigating the relationship between serum levels of C-reactive protein (CRP) and different types of stroke and its severity
TLDR
The results of this study indicated that the level of CRP on admission and four days after the admission of patients with stroke is closely correlated with ischemic stroke severity so that increasing severity of stroke causes an increase in level ofCRP.
Inflammation marker ESR is effective in predicting outcome of diffuse large B-cell lymphoma
TLDR
This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma patients and demonstrated that ESR level is an independent prognostic factor of both OS and PFS.
Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus
TLDR
Aberrant Cys C expression and its clinical associations in NT2DM suggest their important role in this disease.
Pilot case-control study to explore the value of intestinal ultrasound in the differentiation of two common diseases involving the ileocecal region: intestinal Behçet's disease and Crohn's disease.
TLDR
IUS can provide useful information for the differential diagnosis of intestinal BD and CD, and was found to be significantly more common in intestinal BD than in CD, whereas small intestine involvement was significantly moreCommon in CD.
...
...

References

SHOWING 1-10 OF 33 REFERENCES
A new, highly sensitive assay for C-reactive protein can aid the differentiation of inflammatory bowel disorders from constipation- and diarrhoea-predominant functional bowel disorders
TLDR
A new, highly sensitive assay for CRP may help to distinguish FBD from IBD, as shown in patients attending a gastroenterology outpatient clinic with symptoms suggestive of lower-bowel disorders.
Serum levels of C‐reactive protein in Crohn's disease and ulcerative colitis
TLDR
C‐reactive protein levels corresponded closely with clinical and pathological indices of relapse, remission and response to therapy in patients with Crohn's disease and provides an objective criterion of inflammatory activity, which may be useful in the assessment, management and study of Crohns disease.
Role of Serology and Routine Laboratory Tests in Childhood Inflammatory Bowel Disease
TLDR
The large majority of children with IBD can be identified with a clinical history and routine laboratory tests as needing an endoscopic procedure with little benefit of adding serology, but when serology is combined with rectal bleeding, Hgb, and ESR, the sensitivity of screening children for IBD is significantly improved.
Red Cell Distribution Width for Assessment of Activity of Inflammatory Bowel Disease
TLDR
Red cell distribution width (RDW) was found to be the most sensitive and specific parameter indicating active UC and CRP was an important marker of active disease for CD.
Relationships between disease activity and serum and fecal biomarkers in patients with Crohn's disease.
  • Jennifer L Jones, E. Loftus, W. Sandborn
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2008
New serological markers in inflammatory bowel disease are associated with complicated disease behaviour
TLDR
The number and magnitude of immune responses to different microbial antigens were shown to be associated with the severity of the disease and the predictive role of serological markers are necessary.
Serological markers for prediction of response to anti-tumor necrosis factor treatment in Crohn's disease
TLDR
In this cohort of infliximab-treated patients, neither ASCA nor pANCA could predict response to treatment, however, the combination pAN CA+/ASCA− might warrant further investigation for its value in predicting nonresponse in patients with refractory luminal disease.
CRP Correlates with Clinical Score in Ulcerative Colitis but Not in Crohn’s Disease
TLDR
It is concluded that the clinical score has a good correlation with CRP in ulcerative colitis except for proctitis, whereas clinical scores has a poor correlation withCRP in Crohn’s disease, particularly in those with clinically quiescent, fibrostenotic, and ileal disease.
Laboratory markers in IBD: useful, magic, or unnecessary toys?
TLDR
Until more data become available, the use of CRP and other laboratory markers should be seen as an additive tool to clinical observation and physical examination rather than a replacement.
...
...