Preliminary, Open-Label, Pilot Study of Add-On Oral Δ9-Tetrahydrocannabinol in Chronic Post-Traumatic Stress Disorder

  title={Preliminary, Open-Label, Pilot Study of Add-On Oral Δ9-Tetrahydrocannabinol in Chronic Post-Traumatic Stress Disorder},
  author={P. Roitman and R. Mechoulam and R. Cooper-Kazaz and A. Shalev},
  journal={Clinical Drug Investigation},
  • P. Roitman, R. Mechoulam, +1 author A. Shalev
  • Published 2014
  • Medicine
  • Clinical Drug Investigation
  • Background and ObjectivesMany patients with post-traumatic stress disorder (PTSD) achieve but partial remission with current treatments. [...] Key Method This open-label study evaluates the tolerance and safety of orally absorbable Δ9-tetrahydrocannabinol (THC) for chronic PTSD.MethodsTen outpatients with chronic PTSD, on stable medication, received 5 mg of Δ9-THC twice a day as add-on treatment.ResultsThere were mild adverse effects in three patients, none of which led to treatment discontinuation.Expand Abstract
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