Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging.

@article{Ragnauth2010PrelaminAA,
  title={Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging.},
  author={Cassandra D Ragnauth and Derek T. Warren and Yiwen Liu and Rosamund McNair and Tamara Tajsic and Nichola 4 Figg and Rukshana Shroff and Jeremy N. Skepper and Catherine M Shanahan},
  journal={Circulation},
  year={2010},
  volume={121 20},
  pages={2200-10}
}
BACKGROUND Hutchinson-Gilford progeria syndrome is a rare inherited disorder of premature aging caused by mutations in LMNA or Zmpste24 that disrupt nuclear lamin A processing, leading to the accumulation of prelamin A. Patients develop severe premature arteriosclerosis characterized by vascular smooth muscle cell (VSMC) calcification and attrition. METHODS AND RESULTS To determine whether defective lamin A processing is associated with vascular aging in the normal population, we examined the… CONTINUE READING

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