Prejunctional modulatory action of neuropeptide Y on peripheral terminals of capsaicin‐sensitive sensory nerves

@article{Giuliani1989PrejunctionalMA,
  title={Prejunctional modulatory action of neuropeptide Y on peripheral terminals of capsaicin‐sensitive sensory nerves},
  author={Sandro Giuliani and Carlo A. Maggi and Alberto Meli},
  journal={British Journal of Pharmacology},
  year={1989},
  volume={98}
}
1 We have determined the effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin‐sensitive primary afferents in the guinea‐pig isolated left atria (reserpine‐pretreatment, atropine in the bath) and bronchi (atropine and indomethacin in the bath) using capsaicin itself and electrical field stimulation as stimuli. 2 In both preparations, NPY inhibited or suppressed the response produced by electrical field stimulation while leaving the response to a submaximal… 

Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin‐sensitive sensory nerves in the isolated guinea‐pig ileum

It is concluded that NPY exerted a prejunctional inhibitory action on transmitter release from peripheral endings of capsaicin‐sensitive nerves at interneuronal synapses.

ATP modulates the efferent function of capsaicin‐sensitive neurones in guinea‐pig isolated atria

It is demonstrated that ATP modulates the efferent function of cardiac NANC nerve endings through prejunctional inhibitory receptors belonging to the P1 type.

α.‐Adrenoceptor modulation of the efferent function of capsaicin‐sensitive sensory neurones in guinea‐pig isolated atria

Results are in keeping with the presence of inhibitory prejunctional α.2‐adrenoceptors on cardiac sensory nerve endings which modulate the efferent function of capsaicin‐sensitive neurones.
...

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