Prejunctional and postjunctional inhibitory actions of eprosartan and candesartan in the isolated rabbit mesenteric artery.

@article{Balt2002PrejunctionalAP,
  title={Prejunctional and postjunctional inhibitory actions of eprosartan and candesartan in the isolated rabbit mesenteric artery.},
  author={Jippe C Balt and M A Mathy and Alexander Nap and Martin Pfaffendorf and Pieter A. van Zwieten},
  journal={Journal of cardiovascular pharmacology},
  year={2002},
  volume={40 1},
  pages={50-7}
}
Effects of angiotensin II type 1 (AT1) receptor antagonists eprosartan and candesartan and AT2 receptor antagonist PD123319 on Ang II-induced facilitation of noradrenergic neurotransmission were investigated in isolated rabbit mesenteric artery under isometric conditions. Sympathoinhibitory potency of AT1 blockers was compared with their potency concerning inhibition of direct vasoconstrictor effect of Ang II. To investigate blockade of presynaptic AT1 and AT2 receptors, effects of Ang II on… CONTINUE READING