Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: long-term outcome.

@article{Glass1994PreirradiationMC,
  title={Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: long-term outcome.},
  author={Jon Glass and Michael L. Gruber and Lawrence M Cher and Fred H Hochberg},
  journal={Journal of neurosurgery},
  year={1994},
  volume={81 2},
  pages={188-95}
}
The treatment of primary central nervous system lymphoma with chemotherapy prior to whole-brain radiation therapy (WBRT) has improved outcome considerably in this previously fatal disease. Complete or partial responses to intravenous methotrexate (3.5 gm/sq m with leucovorin rescue every 3 weeks for two to four cycles) were seen in 12 of 13 patients originally treated. A total of 25 patients (including the original 13) have now been treated with one to six cycles of methotrexate every 10 to 21… CONTINUE READING
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