Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: a phase II study.

@article{Kovnar1990PreirradiationCA,
  title={Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: a phase II study.},
  author={Edward H. Kovnar and Stewart J. Kellie and Marc E. Horowitz and Robert. A. Sanford and James William Langston and Raymond K. Mulhern and Jesse J. Jenkins and Edwin C. Douglass and E E Etcubanas and Diane L. Fairclough},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1990},
  volume={8 2},
  pages={
          330-6
        }
}
Medulloblastoma, pineoblastoma, and cerebral neuroblastoma are malignant embryonal tumors of the CNS that may demonstrate similar histologic features, a propensity for neuraxis dissemination and sensitivity to radiation therapy and, in certain cases, chemotherapy. To evaluate the activity of preirradiation chemotherapy in such tumors, 11 newly diagnosed children with measurable residual disease and characteristics indicative of poor prognosis were treated postoperatively with cisplatin (CDDP… CONTINUE READING
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