Preimplantation lethality of monosomy for mouse chromosome 19

  title={Preimplantation lethality of monosomy for mouse chromosome 19},
  author={Charles J. Epstein and Bruce Travis},
IT remains a mystery why autosomal trisomy is found more frequently than autosomal monosomy in man. Several surveys of spontaneous abortions have revealed these chromosomal abnormalities in proportions of 26% (ref. 1) and 0.1% (refs 1, 2), respectively, while a prospective study of 47,000 newborn babies revealed no full monosomy and only five cases in which parts of chromosomes were missing3. Similarly, in mouse embryos from translocation stocks bred to produce aneuploid progeny, high… CONTINUE READING


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