Preimplantation genetic diagnosis in 10 couples at risk for transmitting beta-thalassaemia major: clinical experience including the initiation of six singleton pregnancies.

@article{Kanavakis1999PreimplantationGD,
  title={Preimplantation genetic diagnosis in 10 couples at risk for transmitting beta-thalassaemia major: clinical experience including the initiation of six singleton pregnancies.},
  author={Emmanuel Kanavakis and Christina Vrettou and Glenn A. Palmer and Maria Tzetis and Minas Mastrominas and J Traeger-Synodinos},
  journal={Prenatal diagnosis},
  year={1999},
  volume={19 13},
  pages={
          1217-22
        }
}
Preimplantation genetic diagnosis (PGD) offers couples at risk for transmitting an inherited disorder the possibility to avoid the need to terminate affected pregnancies, since it allows the selection of unaffected IVF embryos for transfer. PGD for monogenic diseases is most commonly accomplished by blastomere biopsy from cleavage stage embryos, followed by polymerase chain reaction (PCR)-based DNA analysis. However, PCR-based DNA analysis of single cells is subject to several problems… CONTINUE READING

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