Preimplantation genetic diagnosis for cancer predisposition syndromes.

  title={Preimplantation genetic diagnosis for cancer predisposition syndromes.},
  author={Claudia Spits and Martine De Rycke and Nele Van Ranst and Willem M J A Verpoest and Willy Lissens and Andr{\'e} C. van Steirteghem and Inge Liebaers and Karen Dora Sermon},
  journal={Prenatal diagnosis},
  volume={27 5},
OBJECTIVES Mutations in the APC, NF2 and BRCA1 genes cause adult-onset cancer predisposition syndromes. Prenatal diagnosis (PND) and selective pregnancy termination for adult-onset disorders is emotionally difficult and, in some cases, socially not well accepted. Preimplantation genetic diagnosis (PGD) appears as an attractive alternative to PND, as it ensures the establishment of a pregnancy free of the mutation from the onset, circumventing the potentially difficult decision of termination of… CONTINUE READING