Preimplantation factor (PIF) analog prevents type I diabetes mellitus (TIDM) development by preserving pancreatic function in NOD mice

@article{Weiss2011PreimplantationF,
  title={Preimplantation factor (PIF) analog prevents type I diabetes mellitus (TIDM) development by preserving pancreatic function in NOD mice},
  author={Lola Weiss and Steve L Bernstein and Richard Jones and Ravi Amunugama and David B. Krizman and Lellean Jebailey and Osnat Hazan and Janna Yachtin and Reut Shiner and Israel Reibstein and Elizabeth Triche and Shimon Slavin and Reuven Or and Eytan R. Barnea},
  journal={Endocrine},
  year={2011},
  volume={40},
  pages={41-54}
}
Preimplantation factor (PIF) is a novel embryo-secreted immunomodulatory peptide. Its synthetic analog (sPIF) modulates maternal immunity without suppression. There is an urgent need to develop agents that could prevent the development of type 1 diabetes mellitus (TIDM). Herein, we examine sPIF’s preventive effect on TIDM development by using acute adoptive-transfer (ATDM) and spontaneously developing (SDM) in non-obese diabetic (NOD) murine models. Diabetes was evaluated by urinary and plasma… CONTINUE READING