Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprints

@article{Cirio2007PreimplantationEO,
  title={Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprints},
  author={Mar{\'i}a Cecilia Cirio and Sarayu Ratnam and Feng Ding and Bonnie Reinhart and Christopher S. Navara and J. Richard Chaillet},
  journal={BMC Developmental Biology},
  year={2007},
  volume={8},
  pages={9 - 9}
}
Identical DNA methylation differences between maternal and paternal alleles in gametes and adults suggest that the inheritance of genomic imprints is strictly due to the embryonic maintenance of DNA methylation. Such maintenance would occur in association with every cycle of DNA replication, including those of preimplantation embryos. The expression of the somatic form of the Dnmt1 cytosine methyltransferase (Dnmt1s) was examined in cleavage-stage preimplantation mouse embryos. Low… CONTINUE READING

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