Preimplantation diagnosis: a realistic option for assisted reproduction and genetic practice

  title={Preimplantation diagnosis: a realistic option for assisted reproduction and genetic practice},
  author={Anver Kuliev and Yury Verlinsky},
  journal={Current Opinion in Obstetrics and Gynecology},
  • A. Kuliev, Y. Verlinsky
  • Published 1 April 2005
  • Medicine, Biology
  • Current Opinion in Obstetrics and Gynecology
Purpose of review Preimplantation genetic diagnosis (PGD) allows genetically disadvantaged couples to reproduce, while avoiding the birth of children with targeted genetic disorders. By ensuring unaffected pregnancies, PGD circumvents the possible need and therefore risks of pregnancy termination. This review will describe the current progress of PGD for Mendelian and chromosomal disorders and its impact on reproductive medicine. Recent findings Indications for PGD have expanded beyond those… 
Preimplantation genetic diagnosis: technology and clinical applications.
Clinical vignettes from The Froedtert Hospital and Medical College of Wisconsin Reproductive Medicine Clinic PGD Program will be presented, including the first single-gene disorder PGD performed in Wisconsin.
Can preimplantation genetic diagnosis overcome recurrent pregnancy failure?
  • M. Lalioti
  • Medicine, Biology
    Current opinion in obstetrics & gynecology
  • 2008
Preimplantation genetic diagnosis can be beneficial for three major subgroups of patients with recurrent pregnancy loss: couples carrying chromosomal translocations; women more than 35 years of age; women of any age whose previous miscarriages were due to fetal aneuploidy.
Preimplantation genetic diagnosis (PGD) for a treatable disorder: Gaucher disease type 1 as a model.
Preimplantation Genetic Diagnosis and Genetic Screening
Both PGD and PGS have been shown to be useful in improving reproductive outcomes and will be discussed in this chapter.
Ethical, legal and social implications of prenatal and preimplantation genetic testing for cancer
The reproductive decisions/choices of at-risk young couples and the ethical, legal and social concerns of prenatal genetic testing and preimplantation genetic diagnosis for susceptibility to hereditary cancer syndromes are discussed.
Obtaining Salvation - Regulation of Access to Preimplantation Genetic Diagnosis for the Selection of Saviour Siblings in Australia
The fundamental basis of the reform proposal is the need for a regulatory system that reflects the scope for moral issues, which arise with the use of PGD for the selection of saviour siblings, which will better achieve the regulatory legitimacy that is required.
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A framework for development of guidelines to be issued jointly by European Society of Human Genetics and European society of Human Reproduction and Embryology for the interface between genetics and ART is outlined.
Preimplantation genetic diagnosis for Donohue syndrome ( Leprechaunism ) : case report
The aim is to report the first case of Donohue syndrome diagnosed after performance of preimplantation genetic diagnosis (PGD) in Turkey.
Human Embryonic Stem Cells as Models for Aneuploid Chromosomal Syndromes
The results presented here suggest that aneuploid embryos can serve as an alternative source for either normal euploid or aneuPLoid hESC lines, which represent an invaluable tool to study developmental aspects of chromosomal abnormalities in humans.


Conception for donation.
This combination of IVF and PGD to create a stem cell donor should be treated as research, not only for the advantages of institutional review and collection of data about adverse effects, but so that federal standards for minimizing risks to children can be applied.
Extending preimplantation genetic diagnosis: the ethical debate. Ethical issues in new uses of preimplantation genetic diagnosis.
It is concluded that except for sex selection of the first child, most current extensions of PGD are ethically acceptable, and provides a framework for evaluating future extensions for nonmedical purposes that are still speculative.
Preimplantation HLA testing.
This is the first known experience of preimplantation HLA typing performed without PGD for a causative gene, providing couples with a realistic option of having HLA-matched offspring to serve as potential donors of stem cells for their affected siblings.
Prognostic role of preimplantation genetic diagnosis for aneuploidy in assisted reproductive technology outcome.
The outcome of the first PGD for aneuploidy may have a predictive role for subsequent attempts in couples at risk of generating chromosomally abnormal embryos.