Preimplantation High-Resolution HLA Sequencing Using Next Generation Sequencing.

@article{Rafati2018PreimplantationHH,
  title={Preimplantation High-Resolution HLA Sequencing Using Next Generation Sequencing.},
  author={Maryam Rafati and Mohammad Mahdi Akhondi and Mohammad Reza Sadeghi and Seyedeh Zahra Tara and Saeed Reza Ghaffari},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2018},
  volume={24 8},
  pages={
          1575-1580
        }
}
Hematopoietic stem cell transplantation (SCT) is the only therapeutic option in a number of heritable hematologic disorders and hematologic cancers. Many parents and families fail to find an HLA-identical donor for their affected family member. In such cases, conceiving for a "savior baby" remains the only option, especially in countries without access to national registries. By means of next generation sequencing (NGS) techniques, in a single experiment on single-cell products of in vitro… CONTINUE READING
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