Preimplantation HLA haplotyping using tri-, tetra-, and pentanucleotide short tandem repeats for HLA matching

@article{Bick2008PreimplantationHH,
  title={Preimplantation HLA haplotyping using tri-, tetra-, and pentanucleotide short tandem repeats for HLA matching},
  author={Sarah L. Bick and David Bick and Brent Elliot Wells and Mark R. Roesler and Estil Y. Strawn and Eduardo C. Lau},
  journal={Journal of Assisted Reproduction and Genetics},
  year={2008},
  volume={25},
  pages={323-331}
}
PurposeTo aid couples wishing to conceive children who are HLA matched to a sibling in need of a hematopoietic progenitor cell transplant, we developed a preimplantation HLA haplotype analysis of embryos that utilizes tri-, tetra-, and pentanucleotide STR markers.MethodsFor preimplantation HLA genotyping, we use polymorphic STR markers located across the HLA and flanking regions, selecting exclusively tri-, tetra-, and pentanucleotide repeats. These markers can be resolved using either… CONTINUE READING

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