Prehospital analgesia in adults using inhaled methoxyflurane

@article{Buntine2007PrehospitalAI,
  title={Prehospital analgesia in adults using inhaled methoxyflurane},
  author={Paul G Buntine and Ogilvie Thom and Franz E. Babl and Michael J Bailey and Stephen Bernard},
  journal={Emergency Medicine Australasia},
  year={2007},
  volume={19}
}
Objective:  For many years, ambulance services throughout Australia have been administering methoxyflurane as a first‐line analgesic agent. However, there is a paucity of literature regarding its efficacy, safety and usage profile. The present study was designed to examine the efficacy of methoxyflurane in adults. 
The use of inhaled methoxyflurine as an analgesic in prehospital care
It has come to the attention of the Faculty of Pre-Hospital Care that methoxyflurine as an inhaler (Penthrox) is being used by doctors involved in various sports. We have particularly noted that it
Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting
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Despite the potential for renal impairment evident when methoxyflurane was used in anaesthetic doses, no significant adverse effects have been reported in the literature, neither in patients nor occupationally, when the dose used is limited to that currently recommended.
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Methoxyflurane (MEOF), a non‐narcotic inhalational anaesthetic, administered with the Penthrox Inhaler is effective in managing acute pain, but its use in emergency departments and hospital wards has been limited.
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Comparison of inhalational methoxyflurane (Penthrox®) and intramuscular tramadol for prehospital analgesia.
TLDR
For the doses of medication used in this implementation study, methoxyflurane was superior in efficacy, speed of onset and administration, but with more minor adverse effects when compared to IM tramadol.
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Penthrox appears to be a safe and efficacious analgesic when administered in analgesic dosages and the addition of an activated charcoal filter to the Penthrox inhaler renders the risk of occupational side effects negligible.
The Reincarnation of Methoxyflurane.
  • S. Ikeda
  • Medicine
    Journal of anesthesia history
  • 2020
A brief history of analgesia in paramedic practice
TLDR
The history of analgesia in paramedic or ambulance practice in the United Kingdom and Australia is described in order to add to the knowledge base for this profession, and to inform the development of strategies to advance pain management practice.
Effectiveness of Prehospital Morphine, Fentanyl, and Methoxyflurane in Pediatric Patients
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    Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors
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TLDR
Intranasal fentanyl and intravenous morphine are equally effective analgesic agents in pediatric patients with moderate to severe acute pain in the out-of-hospital setting and Methoxyflurane is less effective in comparison with both morphine and fentanyl, but is an effective opioid in the majority of children.
Effectiveness of Morphine, Fentanyl, and Methoxyflurane in the Prehospital Setting
TLDR
Inhaled methoxyflurane, IN fentanyl, and IV morphine are all effective analgesic agents in the out-of-hospital setting and morphine appears to be more effective than IN fentanyl; however, the benefit of IV morphine may be offset to some degree by the ability to administer IN fentanyl without the need for IV access.
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Objective:  Despite widespread use of methoxyflurane as an inhaled analgesic by ambulance services in Australia there are no published data as to its use pattern, efficacy and safety in the
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