Prehospital analgesia in adults using inhaled methoxyflurane

@article{Buntine2007PrehospitalAI,
  title={Prehospital analgesia in adults using inhaled methoxyflurane},
  author={Paul G Buntine and Ogilvie Thom and Franz E. Babl and Michael J Bailey and Stephen Bernard},
  journal={Emergency Medicine Australasia},
  year={2007},
  volume={19}
}
Objective:  For many years, ambulance services throughout Australia have been administering methoxyflurane as a first‐line analgesic agent. However, there is a paucity of literature regarding its efficacy, safety and usage profile. The present study was designed to examine the efficacy of methoxyflurane in adults. 
The use of inhaled methoxyflurine as an analgesic in prehospital care
It has come to the attention of the Faculty of Pre-Hospital Care that methoxyflurine as an inhaler (Penthrox) is being used by doctors involved in various sports. We have particularly noted that it
Rapid Administration of Methoxyflurane to Patients in the Emergency Department (RAMPED) Study: A Randomized Controlled Trial of Methoxyflurane Versus Standard Care
  • L. Brichko, R. Gaddam, B. Mitra
  • Medicine
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
  • 2020
The objective was to evaluate the effectiveness of methoxyflurane versus standard care for the initial management of severe pain among adult emergency department (ED) patients.
Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting
TLDR
Despite the potential for renal impairment evident when methoxyflurane was used in anaesthetic doses, no significant adverse effects have been reported in the literature, neither in patients nor occupationally, when the dose used is limited to that currently recommended.
Stability of Methoxyflurane Loaded Penthrox Inhaler
TLDR
Methoxyflurane (MEOF), a non‐narcotic inhalational anaesthetic, administered with the Penthrox Inhaler is effective in managing acute pain, but its use in emergency departments and hospital wards has been limited.
Efficacy of inhaled methoxyflurane for procedural analgesia in paediatric burns: a pilot study
TLDR
Data showed that the incidence of hospitalised paediatric burn patients is highest in Africa, and in Sub-Saharan Africa, 83.6% of all burn injuries occurred in children between the ages 0–10.
Comparison of inhalational methoxyflurane (Penthrox®) and intramuscular tramadol for prehospital analgesia.
TLDR
For the doses of medication used in this implementation study, methoxyflurane was superior in efficacy, speed of onset and administration, but with more minor adverse effects when compared to IM tramadol.
Efficacy and safety of methoxyflurane: managing trauma associated pain in UK SAR helicopter paramedic practice
TLDR
Penthrox appears to be a safe and efficacious analgesic when administered in analgesic dosages and the addition of an activated charcoal filter to the Penthrox inhaler renders the risk of occupational side effects negligible.
The Reincarnation of Methoxyflurane.
  • S. Ikeda
  • Medicine
    Journal of anesthesia history
  • 2020
Methoxyflurane as an analgesic for prehospital use at high altitude.
TLDR
Evidence is suggested that in childbirth there is evidence to suggest that methoxyflurane is not only a more effective analgesic than Entonox, but it also has a lower incidence of side effects such as nausea and restlessness.
A brief history of analgesia in paramedic practice
TLDR
The history of analgesia in paramedic or ambulance practice in the United Kingdom and Australia is described in order to add to the knowledge base for this profession, and to inform the development of strategies to advance pain management practice.
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