Prehospital analgesia in adults using inhaled methoxyflurane

  title={Prehospital analgesia in adults using inhaled methoxyflurane},
  author={Paul G Buntine and Ogilvie Thom and Franz E. Babl and Michael J Bailey and Stephen Bernard},
  journal={Emergency Medicine Australasia},
Objective:  For many years, ambulance services throughout Australia have been administering methoxyflurane as a first‐line analgesic agent. However, there is a paucity of literature regarding its efficacy, safety and usage profile. The present study was designed to examine the efficacy of methoxyflurane in adults. 
The use of inhaled methoxyflurine as an analgesic in prehospital care
It has come to the attention of the Faculty of Pre-Hospital Care that methoxyflurine as an inhaler (Penthrox) is being used by doctors involved in various sports. We have particularly noted that it
Rapid Administration of Methoxyflurane to Patients in the Emergency Department (RAMPED) Study: A Randomized Controlled Trial of Methoxyflurane Versus Standard Care
  • L. Brichko, R. Gaddam, B. Mitra
  • Medicine
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
  • 2020
The objective was to evaluate the effectiveness of methoxyflurane versus standard care for the initial management of severe pain among adult emergency department (ED) patients.
Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting
Despite the potential for renal impairment evident when methoxyflurane was used in anaesthetic doses, no significant adverse effects have been reported in the literature, neither in patients nor occupationally, when the dose used is limited to that currently recommended.
Stability of Methoxyflurane Loaded Penthrox Inhaler
Methoxyflurane (MEOF), a non‐narcotic inhalational anaesthetic, administered with the Penthrox Inhaler is effective in managing acute pain, but its use in emergency departments and hospital wards has been limited.
Efficacy of inhaled methoxyflurane for procedural analgesia in paediatric burns: a pilot study
Data showed that the incidence of hospitalised paediatric burn patients is highest in Africa, and in Sub-Saharan Africa, 83.6% of all burn injuries occurred in children between the ages 0–10.
Comparison of inhalational methoxyflurane (Penthrox®) and intramuscular tramadol for prehospital analgesia.
For the doses of medication used in this implementation study, methoxyflurane was superior in efficacy, speed of onset and administration, but with more minor adverse effects when compared to IM tramadol.
Efficacy and safety of methoxyflurane: managing trauma associated pain in UK SAR helicopter paramedic practice
Penthrox appears to be a safe and efficacious analgesic when administered in analgesic dosages and the addition of an activated charcoal filter to the Penthrox inhaler renders the risk of occupational side effects negligible.
The Reincarnation of Methoxyflurane.
  • S. Ikeda
  • Medicine
    Journal of anesthesia history
  • 2020
Methoxyflurane as an analgesic for prehospital use at high altitude.
Evidence is suggested that in childbirth there is evidence to suggest that methoxyflurane is not only a more effective analgesic than Entonox, but it also has a lower incidence of side effects such as nausea and restlessness.
A brief history of analgesia in paramedic practice
The history of analgesia in paramedic or ambulance practice in the United Kingdom and Australia is described in order to add to the knowledge base for this profession, and to inform the development of strategies to advance pain management practice.


Inhaled methoxyflurane as a prehospital analgesic in children
Objective:  Despite widespread use of methoxyflurane as an inhaled analgesic by ambulance services in Australia there are no published data as to its use pattern, efficacy and safety in the
MethoxyfluraDe analgesia by Cyprane inhaler
Good records showing the exact timing and amount of each dose, the blood pressure before and after the dose and the analgesic effect are essential where several persons may be involved in the treatment.
Renal failure following methoxyflurane analgesia.
Two patients given methoxyflurane for analgesia over 14 and 16 days developed renal failure and died. The inhaler was withdrawn from the New Zealand market in 1984.
Methoxyflurane analgesia for burns dressings: experience with the analgizer.
Methoxyflurane has been used to provide analgesia for burns dressings on sixty occasions in eleven patients by way of a new, disposable vaporizer, the Analgizer, which is described.
Use of Entonox in the Ambulance Service
An analgesic mixture of nitrous oxide and oxygen (Entonox) has been used in nine ambulances in Gloucestershire for self-administration by patients in severe pain and the pain was wholly or partially relieved, and in no instance was the patient's condition worsened.
Methoxyflurane analgesia for burns dressings
The requirements for analgesia for burns dressings are discussed. Methoxyflurane has proved satisfactory in a clinical trial, and can be administered by one of two types of vaporizer. The possibility
Options in prehospital analgesia.
The present paper identifies the analgesia methods currently available in the prehospital setting so as to evaluate the various options and highlight areas for future research.
Prehospital identification and treatment of pain for patients with musculoskeletal trauma could be improved, and administration of analgesics to prehospital patients with suspected fractures was rare.
The effect of pre-hospital administration of intravenous nalbuphine on on-scene times.
Compared the time spent on-scene by ambulance crews treating patients with fractures of the tibia and fibula who received intravenous nalbuphine with those who had placement of an intravenous cannula alone, the benefits of effective pre-hospital analgesia have a cost in terms of time.
Prehospital use of analgesia for suspected extremity fractures.
  • L. White, J. Cooper, R. Chambers, R. Gradisek
  • Medicine
    Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors
  • 2000
Administration of analgesics to prehospital patients with suspected fractures was rare and prehospital identification and treatment of pain for patients with musculoskeletal trauma could be improved.