Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swine.

@article{Patel2006PrehospitalHA,
  title={Prehospital HBOC-201 after traumatic brain injury and hemorrhagic shock in swine.},
  author={Mayur B. Patel and Ara J. Feinstein and Alvaro D Saenz and Matthias Majetschak and Kenneth G. Proctor},
  journal={The Journal of trauma},
  year={2006},
  volume={61 1},
  pages={46-56}
}
BACKGROUND Data are limited on the actions of hemoglobin based oxygen carriers (HBOCs) after traumatic brain injury (TBI). This study evaluates neurotoxicity, vasoactivity, cardiac toxicity, and inflammatory activity of HBOC-201 (Biopure, Cambridge, Mass.) resuscitation in a TBI model. METHODS Swine received TBI and hemorrhage. After 30 minutes, resuscitation was initiated with 10 mL/kg normal saline (NS), followed by either HBOC-201 (6 mL/kg, n = 10) or NS control (n = 10). Supplemental NS… CONTINUE READING