Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

@article{Wu1991PregnenoloneSA,
  title={Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.},
  author={Felix S. Wu and Terrell T. Gibbs and David H. Farb},
  journal={Molecular pharmacology},
  year={1991},
  volume={40 3},
  pages={333-6}
}
The N-methyl-D-aspartate (NMDA) receptor is believed to play a major role in learning and in excitotoxic neuronal damage associated with stroke and epilepsy. Pregnenolone sulfate, a neurosteroid, specifically enhances NMDA-gated currents in spinal cord neurons, while inhibiting receptors for the inhibitory amino acids glycine and gamma-aminobutyric acid, as well as non-NMDA glutamate receptors. This observation is consistent with the hypothesis that neurosteroids such as pregnenolone sulfate… CONTINUE READING
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