Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence
@article{Marx2011PregnenoloneAA, title={Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence}, author={C. Marx and D. Bradford and R. Hamer and J. Naylor and J. Kilts}, journal={Neuroscience}, year={2011}, volume={191}, pages={78-90} }
Emerging preclinical and clinical evidence suggests that pregnenolone may be a promising novel therapeutic candidate in schizophrenia. Pregnenolone is a neurosteroid with pleiotropic actions in rodents that include the enhancement of learning and memory, neuritic outgrowth, and myelination. Further, pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis… CONTINUE READING
Topics from this paper
107 Citations
Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice
- Medicine
- PloS one
- 2012
- 41
- PDF
Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia
- Medicine
- Psychopharmacology
- 2014
- 40
Pregnenolone sulfate as a modulator of synaptic plasticity
- Chemistry, Medicine
- Psychopharmacology
- 2014
- 29
Neurosteroids and potential therapeutics: Focus on pregnenolone
- Biology, Medicine
- The Journal of Steroid Biochemistry and Molecular Biology
- 2016
- 30
Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress
- Psychology, Medicine
- Schizophrenia Research
- 2015
- 18
- PDF
Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia
- Medicine
- Psychoneuroendocrinology
- 2018
- 11
Neurosteroid pregnenolone sulfate, alone, and as augmentation of lurasidone or tandospirone, rescues phencyclidine-induced deficits in cognitive function and social interaction
- Medicine
- Behavioural Brain Research
- 2018
- 7
Stress and drug abuse-related disorders: The promising therapeutic value of neurosteroids focus on pregnenolone-progesterone-allopregnanolone pathway
- Medicine
- Frontiers in Neuroendocrinology
- 2019
- 3
Progesterone and its metabolites as therapeutic targets in psychiatric disorders
- Medicine
- Expert opinion on therapeutic targets
- 2014
- 17
References
SHOWING 1-10 OF 154 REFERENCES
Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: Candidate mechanism for superior efficacy?
- Medicine
- Pharmacology Biochemistry and Behavior
- 2006
- 64
Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia
- Psychology, Medicine
- Neuropsychopharmacology
- 2009
- 156
- PDF
Neuroactive steroids and inhibitory neurotransmission: Mechanisms of action and physiological relevance
- Chemistry, Medicine
- Neuroscience
- 2006
- 156
Steroid structure and pharmacological properties determine the anti‐amnesic effects of pregnenolone sulphate in the passive avoidance task in rats
- Chemistry, Medicine
- The European journal of neuroscience
- 2001
- 32
Glutamate as a therapeutic target in psychiatric disorders
- Biology, Medicine
- Molecular Psychiatry
- 2004
- 456
- PDF
Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.
- Chemistry, Medicine
- The international journal of neuropsychopharmacology
- 2008
- 12
- PDF
Nanomolar Concentrations of Pregnenolone Sulfate Enhance Striatal Dopamine Overflow in Vivo
- Biology, Medicine
- Journal of Pharmacology and Experimental Therapeutics
- 2008
- 11
Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions.
- Psychology, Medicine
- International review of neurobiology
- 2007
- 469
In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis
- Psychology, Medicine
- Behavioural pharmacology
- 2010
- 60
N-Methyl-d-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives
- Psychology, Medicine
- Psychopharmacology
- 2005
- 219