• DOI:10.1016/j.neuroscience.2011.06.076
Corpus ID: 26396652

Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence

@article{Marx2011PregnenoloneAA,
  title={Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence},
  author={C. Marx and D. Bradford and R. Hamer and J. Naylor and J. Kilts},
  journal={Neuroscience},
  year={2011},
  volume={191},
  pages={78-90}
}

C. Marx, D. Bradford, +2 authors J. Kilts

Published 2011

Psychology, Medicine

Neuroscience

Emerging preclinical and clinical evidence suggests that pregnenolone may be a promising novel therapeutic candidate in schizophrenia. Pregnenolone is a neurosteroid with pleiotropic actions in rodents that include the enhancement of learning and memory, neuritic outgrowth, and myelination. Further, pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis… CONTINUE READING

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