Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence

  title={Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence},
  author={C. Marx and D. Bradford and R. Hamer and J. Naylor and J. Kilts},
  • C. Marx, D. Bradford, +2 authors J. Kilts
  • Published 2011
  • Psychology, Medicine
  • Neuroscience
  • Emerging preclinical and clinical evidence suggests that pregnenolone may be a promising novel therapeutic candidate in schizophrenia. Pregnenolone is a neurosteroid with pleiotropic actions in rodents that include the enhancement of learning and memory, neuritic outgrowth, and myelination. Further, pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis… CONTINUE READING
    107 Citations
    Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice
    • 41
    • PDF
    Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia
    • 40
    Pregnenolone sulfate as a modulator of synaptic plasticity
    • 29
    Neurosteroids and potential therapeutics: Focus on pregnenolone
    • M. Vallée
    • Biology, Medicine
    • The Journal of Steroid Biochemistry and Molecular Biology
    • 2016
    • 30
    Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress
    • 18
    • PDF
    Nongenomic actions of neurosteroid pregnenolone and its metabolites
    • 21
    Progesterone and its metabolites as therapeutic targets in psychiatric disorders
    • 17


    Glutamate as a therapeutic target in psychiatric disorders
    • D. Javitt
    • Biology, Medicine
    • Molecular Psychiatry
    • 2004
    • 456
    • PDF
    Nanomolar Concentrations of Pregnenolone Sulfate Enhance Striatal Dopamine Overflow in Vivo
    • 11
    Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions.
    • D. Javitt
    • Psychology, Medicine
    • International review of neurobiology
    • 2007
    • 469