Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.

@article{Marek2005Pregnenolone16alphacarbonitrileIR,
  title={Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.},
  author={C. J. Marek and S. Tucker and Dimitrios K. Konstantinou and L. Elrick and D. Haefner and C. Sigalas and G. Murray and B. Goodwin and M. C. Wright},
  journal={The Biochemical journal},
  year={2005},
  volume={387 Pt 3},
  pages={
          601-8
        }
}
The effect of liver growth stimulation [using the rodent PXR (pregnane X receptor) activator PCN (pregnenolone-16alpha-carbonitrile)] in rats chronically treated with carbon tetrachloride to cause repeated hepatocyte necrosis and liver fibrogenesis was examined. PCN did not inhibit the hepatotoxicity of carbon tetrachloride. However, transdifferentiation of hepatic stellate cells and the extent of fibrosis caused by carbon tetrachloride treatment was significantly inhibited by PCN in vivo. In… Expand
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