Pregnenolone, dehydroepiandrosterone, and their sulfate and fatty acid esters in the rat brain.

@article{Jo1989PregnenoloneDA,
  title={Pregnenolone, dehydroepiandrosterone, and their sulfate and fatty acid esters in the rat brain.},
  author={Do Hyun Jo and Mohamed Abou-Elwafa Abdallah and Jennifer E. Young and Etienne Emile Baulieu and Paul Robel},
  journal={Steroids},
  year={1989},
  volume={54 3},
  pages={287-97}
}
The rat brain contains large amounts of pregnenolone (P) and dehydroepiandrosterone (D) arising from local biosynthetic pathways. We have devised a procedure for the measurement of both "neurosteroids" either unconjugated or released from their sulfate (S) or fatty acid (L) esters. The measurements were performed at the acrophase of the circadian variation of neurosteroids, and confirmed the large accumulation of P (25 +/- 8 ng/g, mean +/- SD) and of PS (19 +/- 6 ng/g) and DS (2.1 +/- 0.5 ng/g… CONTINUE READING

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