Pregnenolone, dehydroepiandrosterone, and schizophrenia: alterations and clinical trials.

@article{Ritsner2010PregnenoloneDA,
  title={Pregnenolone, dehydroepiandrosterone, and schizophrenia: alterations and clinical trials.},
  author={Michael S. Ritsner},
  journal={CNS neuroscience & therapeutics},
  year={2010},
  volume={16 1},
  pages={32-44}
}
Neurosteroids, such as pregnenolone (PREG), dehydroepiandrosterone (DHEA), and their sulfates (PREGS and DHEAS) are reported to have a modulatory effect on neuronal excitability and synaptic plasticity. They also have many other functions associated with neuroprotection, response to stress, mood regulation, and cognitive performance. Furthermore, these neurosteroids have been linked to, and their levels are altered in, neuropsychiatric disorders. This review highlights what is currently known… CONTINUE READING
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