Pregnant rats are refractory to the natriuretic actions of atrial natriuretic peptide.

@article{Masilamani1994PregnantRA,
  title={Pregnant rats are refractory to the natriuretic actions of atrial natriuretic peptide.},
  author={Shyama M E Masilamani and Leticia Alonso Castro and Chris Baylis},
  journal={The American journal of physiology},
  year={1994},
  volume={267 6 Pt 2},
  pages={R1611-6}
}
Normal pregnant women and rats undergo a volume expansion. Atrial natriuretic peptide (ANP) is involved in volume homeostasis and is stimulated in response to volume expansion in nonpregnant animals, resulting in natriuresis and diuresis. The conscious, chronically catheterized rat was used to measure mean arterial blood pressure (MABP) and renal responses to administered ANP (160 ng.kg-1.min-1 i.v.) to determine if the actions of ANP are altered by pregnancy. These experiments examined virgin… CONTINUE READING

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