Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice.

Abstract

Human immunodeficiency virus (HIV) protease inhibitors (PIs) have been used successfully in extending the life span of people infected with HIV. The use of PIs has also been associated with dyslipidemia and an increased risk of cardiovascular disease, but the underlying mechanisms remain elusive. Several PIs have been implicated in activating the nuclear… (More)
DOI: 10.1124/mol.113.085753

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