Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.

@article{Kodama2011PregnaneXR,
  title={Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.},
  author={Susumu Kodama and Masahiko Negishi},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 5},
  pages={3570-8}
}
Pregnane X receptor (PXR) was originally characterized as a transcription factor that induces hepatic drug metabolism by activating cytochrome P450 genes. Here we have now demonstrated a novel function of PXR, that of eliciting p38 mitogen-activated protein kinase (MAPK) phosphorylation for cell migration. Upon xenobiotic activation of ectopic human PXR, human hepatocellular carcinoma HepG2 cells were found to exhibit increased phosphorylation of p38 MAPK and to subsequently change morphology… CONTINUE READING

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