Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR.

@article{Ott2009PregnaneXR,
  title={Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR.},
  author={Melanie Ott and Gert Fricker and Bjoern Bauer},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={329 1},
  pages={141-9}
}
Pharmacotherapy of central nervous system (CNS) disorders is impaired by the drug efflux transporter, P-glycoprotein, which limits drug penetration across the blood-brain barrier into the CNS. One strategy to increase brain drug levels is to modulate P-glycoprotein regulation. This approach requires understanding of the mechanisms that control transporter expression and function. One mechanism through which P-glycoprotein is regulated is the nuclear receptor, pregnane X receptor (PXR… CONTINUE READING
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