Pregnane X Receptor and Cancer: Context-Specificity is Key.

@article{Pondugula2016PregnaneXR,
  title={Pregnane X Receptor and Cancer: Context-Specificity is Key.},
  author={Satyanarayana R. Pondugula and Petr P{\'a}vek and Sridhar Mani},
  journal={Nuclear receptor research},
  year={2016},
  volume={3}
}
Pregnane X receptor (PXR) is an adopted orphan nuclear receptor that is activated by a wide-range of endobiotics and xenobiotics, including chemotherapy drugs. PXR plays a major role in the metabolism and clearance of xenobiotics and endobiotics in liver and intestine via induction of drug-metabolizing enzymes and drug-transporting proteins. However, PXR is… CONTINUE READING