Pregnancy status and fetal prion genetics determine PrPSc accumulation in placentomes of scrapie-infected sheep.

@article{Tuo2002PregnancySA,
  title={Pregnancy status and fetal prion genetics determine PrPSc accumulation in placentomes of scrapie-infected sheep.},
  author={W. M. H. Tuo and K. I. O'Rourke and Dongyue Zhuang and William P. Cheevers and Terry R Spraker and Donald P. Knowles},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 9},
  pages={6310-5}
}
Ovine scrapie is a fatal neurodegenerative disorder that may be transmitted through exposure to infected uterine and placental tissues. Susceptibility to scrapie is primarily controlled by polymorphisms in the prion protein (PrP) gene. Scrapie in the U.S. Suffolk breed and in many breeds in Europe occurs in sheep homozygous for glutamine (171QQ), but rarely in sheep heterozygous for glutamine and arginine (171QR) or homozygous for arginine (171RR) at codon 171 of the PrP gene. This study… CONTINUE READING

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Vertebrate Fetal Membranes (Rutgers

H. W. Mossman
1987

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