Pregnancy restores insulin secretion from pancreatic islets in cafeteria diet-induced obese rats.

@article{Vanzela2010PregnancyRI,
  title={Pregnancy restores insulin secretion from pancreatic islets in cafeteria diet-induced obese rats.},
  author={Emerielle Cristine Vanzela and Rosane Aparecida Ribeiro and Camila Andrea de Oliveira and Fabiana B Rodrigues and Maria L{\'u}cia Bonfleur and Everardo Magalh{\~a}es Carneiro and Kleber L.A. Souza and Ant{\^o}nio Carlos Boschero},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2010},
  volume={298 2},
  pages={R320-8}
}
Insulin resistance during pregnancy is counteracted by enhanced insulin secretion. This condition is aggravated by obesity, which increases the risk of gestational diabetes. Therefore, pancreatic islet functionality was investigated in control nonpregnant (C) and pregnant (CP), and cafeteria diet-fed nonpregnant (Caf), and pregnant (CafP) obese rats. Isolated islets were used for measurements of insulin secretion (RIA), NAD(P)H production (MTS), glucose oxidation ((14)CO(2) production… CONTINUE READING

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