Pregnancy outcomes following first‐trimester exposure to topical retinoids: a systematic review and meta‐analysis

@article{Kaplan2015PregnancyOF,
  title={Pregnancy outcomes following first‐trimester exposure to topical retinoids: a systematic review and meta‐analysis},
  author={Yusuf Cem Kaplan and Jak Ozsarfati and Fatma Etwel and Cheri Nickel and Irena Nulman and Gideon Koren},
  journal={British Journal of Dermatology},
  year={2015},
  volume={173}
}
Evaluation of human data regarding the outcomes of topical‐retinoid‐exposed pregnancies is important in terms of counselling pregnant women with inadvertent exposure. The objective of this study was thus to determine whether exposure to topical retinoids leads to an increase in the risk of adverse pregnancy outcomes. We carried out a search using the Medline, Embase, Web of Science and Cochrane Central Register of Controlled Trials databases from inception to 4 December 2014. The selection… 

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References

SHOWING 1-10 OF 50 REFERENCES

Pregnancy Outcome Following Exposure to Topical Retinoids: A Multicenter Prospective Study

The results do not suggest an increased risk of retinoid embryopathy, but according to current knowledge, topical retinoids cannot be advised for use during pregnancy because their risk/benefit ratio remains questionable.

Retinoic acid embryopathy.

It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.

Topical tretinoin and fetal malformations

The neuropathology of this case (the first in Australia) of severe craniofacial and central nervous system malformations in a baby girl, born at term, whose mother had been exposed to topical retinoic acid during pregnancy is described.

Negligible Systemic Absorption of Topical Isotretinoin Cream: Implications for Teratogenicity

The minimal systemic availability of isotretinoin cream compared with the U.S. recommended daily allowance for vitamin A supplements provides reasonable evidence for lack of its potential teratogenic risk.

Embryotoxicity and teratogenicity of topical retinoic acid.

  • H. Nau
  • Medicine, Biology
    Skin pharmacology : the official journal of the Skin Pharmacology Society
  • 1993
The highly specific spatial and temporal distribution of binding proteins and nuclear receptors in the embryo suggests that even small alterations in endogenous levels of all-trans-retinoic acid in the embryos may alter crucial developmental processes such as morphogenes; this aspect should be further investigated.

Tretinoin: a review of the nonclinical developmental toxicology experience.