Pregnancy outcomes following first‐trimester exposure to topical retinoids: a systematic review and meta‐analysis

  title={Pregnancy outcomes following first‐trimester exposure to topical retinoids: a systematic review and meta‐analysis},
  author={Yusuf Cem Kaplan and Jak Ozsarfati and Fatma Etwel and Cheri Nickel and Irena Nulman and Gideon Koren},
  journal={British Journal of Dermatology},
Evaluation of human data regarding the outcomes of topical‐retinoid‐exposed pregnancies is important in terms of counselling pregnant women with inadvertent exposure. The objective of this study was thus to determine whether exposure to topical retinoids leads to an increase in the risk of adverse pregnancy outcomes. We carried out a search using the Medline, Embase, Web of Science and Cochrane Central Register of Controlled Trials databases from inception to 4 December 2014. The selection… 

What is the risk of inadvertent exposure to topical retinoids during first trimester pregnancy?

  • Y. Tada
  • Medicine
    The British journal of dermatology
  • 2015
First-trimester exposure to topical retinoids did not significantly increase the rates of major congenital malformations, spontaneous abortions, stillbirth, elective termination of pregnancy, low birth weight or prematurity, and clinical studies are needed to analyse the safety of individual drugs.

Use of Topical Tazarotene for the Treatment of Acne Vulgaris in Pregnancy: A Literature Review.

The goal of this literature review was to provide historical context for the pregnancy labeling rule for tazarotene compared with other approved retinoids and gather available data on tazerotene- and retinoid-related pregnancy outcomes.

Teratogen update: Topical use and third‐generation retinoids

It is recommended that the use of topical retinoids during pregnancy be avoided, however, in circumstances when inadvertent exposure in pregnancy may occur, the available data provide some reassurance that adverse pregnancy outcomes are unlikely.

Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescents

The Pediatric Dermatology Research Alliance (PeDRA) Use of Retinoid in Ichthyosis Work Group was formed to address issues and to establish best practices regarding the use of retinoids in ichthyoses based on available evidence and expert opinion.

Treatment of Acne in Pregnancy

The safety profile of common therapies and outline approaches based on available evidence are described, including complementary therapies including micronutrients and nonpharmacologic treatments seem to be well tolerated.

Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations

There is a lack of evidence from properly designed clinical trials to support the claimed efficacy of the most commonly used retinoids as antiaging agents in cosmeceuticals, but the promising potential of retinoid nanoformulations requires a more comprehensive evaluation with additional studies to supportThe preliminary findings.

Erythrodermic psoriasis: pathophysiology and current treatment perspectives

The latest data with regard to the treatment of EP, which includes biologic therapies such as ustekinumab and ixekizumab are reviewed, which suggests that the disease is associated with a predominantly T helper 2 (Th2) phenotype.

An investigational study to assess patient beliefs and informational sources regarding the safety and use of sunscreen

A prominent nonprofit organization has made public claims that sunscreens are toxic, can alter hormone levels, and cause birth defects and cancer, which have been perpetuated by the media.

Testing The Effectiveness of The Pregnancy of Centella Asiatica Leaf Extract Gel Formula 10% for Striae Gravidarum Management in Pregnant Women

Gel preparation of Centella asiatica leaves extract formula (10%) is effective for treatment of striae gravidarum grade 1,2 and 3.



Pregnancy Outcome Following Exposure to Topical Retinoids: A Multicenter Prospective Study

The results do not suggest an increased risk of retinoid embryopathy, but according to current knowledge, topical retinoids cannot be advised for use during pregnancy because their risk/benefit ratio remains questionable.

Retinoic acid embryopathy.

It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.

Topical tretinoin and fetal malformations

The neuropathology of this case (the first in Australia) of severe craniofacial and central nervous system malformations in a baby girl, born at term, whose mother had been exposed to topical retinoic acid during pregnancy is described.

Negligible Systemic Absorption of Topical Isotretinoin Cream: Implications for Teratogenicity

The minimal systemic availability of isotretinoin cream compared with the U.S. recommended daily allowance for vitamin A supplements provides reasonable evidence for lack of its potential teratogenic risk.

Embryotoxicity and teratogenicity of topical retinoic acid.

  • H. Nau
  • Medicine, Biology
    Skin pharmacology : the official journal of the Skin Pharmacology Society
  • 1993
The highly specific spatial and temporal distribution of binding proteins and nuclear receptors in the embryo suggests that even small alterations in endogenous levels of all-trans-retinoic acid in the embryos may alter crucial developmental processes such as morphogenes; this aspect should be further investigated.

Tretinoin: a review of the nonclinical developmental toxicology experience.