Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview

@article{Ghazeeri2012PregnancyOA,
  title={Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview},
  author={Ghina Ghazeeri and Anwar H. Nassar and Zeina M H Younes and Johnny Awwad},
  journal={Acta Obstetricia et Gynecologica Scandinavica},
  year={2012},
  volume={91}
}
This article is a review of the literature assessing pregnancy outcomes and the effect of metformin treatment among women with polycystic ovary syndrome (PCOS). A review of research published in English was undertaken using PubMed and MEDLINE databases. The weight of the available evidence suggests that pregnant women with PCOS are at an increased risk of developing gestational diabetes, hypertensive disorders of pregnancy, preterm birth and early pregnancy loss. Obesity is a contributory… Expand
Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis
TLDR
Metformin therapy throughout pregnancy can reduce the RR of miscarriage and premature birth incidence in PCOS patients with no serious side effects. Expand
Effects of Metformin on Pregnancy Outcomes in Women with Polycystic Ovary Syndrome during First Trimester
TLDR
Good maternal outcomes in women with polycystic ovary syndrome who continued metformin during first trimester including decrease incidence of spontaneous miscarriage and gastrointestinal diabetes mellitus are found. Expand
Metformin for preventing gestational diabetes in women with polycystic ovarian syndrome.
TLDR
The frequency of gestational diabetes, was significantly higher in patients with PCOS who had not received metformin compared to those who did, and the odds ratio for GDM during pregnancy was 4.7 times likely to have GDM compared to patients who received it. Expand
Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis.
TLDR
The higher association of pregnancy complications and PCOS compared with patients who do not have PCOS is confirmed and there may be a stronger association between PCOS and hypertensive disorders than has been shown previously. Expand
The effects of polycystic ovary syndrome on gestational diabetes mellitus
TLDR
It is demonstrated that the presence of polycystic ovary syndrome along with gestational diabetes mellitus increases the risk of pregnancy induced hypertension by 2.4 fold, preeclampsia by 2 fold and neonatal hypoglycemia by 3.2 fold, compared to gestational Diabetes mellitus alone. Expand
Women with PCOS with a History of Early Pregnancy Loss Show a Higher Risk of Gestational Diabetes Mellitus
TLDR
Both a history of EPL and obesity are risk factors for GDM for PCOS women, and higher BMI indicates a higher possibility of GDM among PCos women with a historyof EPL. Expand
Menstrual preconditioning for the prevention of major obstetrical syndromes in polycystic ovary syndrome.
TLDR
It is proposed that induction of ovulation in the infertile nulligravid woman with PCOS should be preceded by a period of progesterone withdrawal bleedings to achieve full endometrial progester one response by the time of pregnancy. Expand
Maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes: A cross-sectional study
TLDR
Considering the higher risk of gestational diabetes mellitus and pregnancy-induced hypertension in PCOS phenotypes A and B, women with these phenotypes need more precise prenatal care. Expand
Association of polycystic ovary syndrome with metabolic syndrome and gestational diabetes: Aggravated complication of pregnancy
TLDR
Different results indicating the complexity of the disease and the need for better controlled studies and additional efforts for PCOS-specific drug discovery are indicated. Expand
PCOS and pregnancy: Impact of endocrine and metabolic factors
TLDR
Lifestyle modification may improve biochemical and endocrinological parameters, preventing progression of PCOS to type 2 diabetes and cardiovascular diseases later in life. Expand
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References

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A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome.
TLDR
In conclusion, women with PCOS are at increased risk of pregnancy and neonatal complications and pre-pregnancy, antenatal and intrapartum care should be aimed at reducing these risks. Expand
Effects of metformin on early pregnancy loss in the polycystic ovary syndrome.
TLDR
Metformin administration during pregnancy reduces first-trimester pregnancy loss in women with the polycystic ovary syndrome. Expand
Impact of Insulin Resistance on Pregnancy Complications and Outcome in Women with Polycystic Ovary Syndrome
TLDR
The frequencies of pre-eclampsia and GDM are increased in PCOS pregnancies, and insulin resistance prior to pregnancy did not further increase the frequency of GDM. Expand
Does continuous use of metformin throughout pregnancy improve pregnancy outcomes in women with polycystic ovarian syndrome?
TLDR
Evaluating pregnancy outcomes in women with PCOS who conceived while on metformin treatment, and continued the medication for a variable length of time during pregnancy found evidence to support the long‐term use of insulin‐sensitizing agents during pregnancy inadequate. Expand
Prevalence of gestational diabetes mellitus and pregnancy outcomes in Asian women with polycystic ovary syndrome
TLDR
The prevalence of GDM in Asian women with PCOS is high and comparable to those of a high-risk group, and the Cesarean section rate was higher in the PCOS than in the control group. Expand
Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis.
TLDR
The higher association of pregnancy complications and PCOS compared with patients who do not have PCOS is confirmed and there may be a stronger association between PCOS and hypertensive disorders than has been shown previously. Expand
Continuation of metformin in the first trimester of women with polycystic ovarian syndrome is not associated with increased perinatal morbidity
TLDR
There is no evidence that the continuation of metformin in the first trimester of pregnancy was associated with an adverse foetal outcome, and it is found that women with polycystic ovary syndrome treated with metformIn in the second trimester were not affected by the drug. Expand
Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study.
TLDR
Metformin treatment from first trimester to delivery did not reduce pregnancy complications in PCOS and women in the metformin group gained less weight during pregnancy compared with those in the placebo group. Expand
Pregnancy in women with polycystic ovary syndrome: the effect of different phenotypes and features on obstetric and neonatal outcomes.
TLDR
The increased risk for adverse obstetric and neonatal outcomes that was observed in patients with PCOS varies widely according to the different phenotypes and features of PCOS. Expand
Maternal polycystic ovary syndrome may be associated with adverse pregnancy outcomes.
TLDR
Women affected by PCOS carry an increased risk of adverse pregnancy outcomes, and the higher occurrence of adverse outcomes may be, at least partly, related to a higher weight gain during pregnancy in PCOS group with respect to the other groups. Expand
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