Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey

@article{Salooja2001PregnancyOA,
  title={Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey},
  author={N. Salooja and R M Szydlo and G{\'e}rard Soci{\'e} and Bernard Rio and Ratna Chatterjee and Per Ljungman and M. T. van Lint and Ray L. Powles and G. Jackson and Margareta Hinterberger-Fischer and H. J. Kolb and J. F. Apperley},
  journal={The Lancet},
  year={2001},
  volume={358},
  pages={271-276}
}
Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: report from the bone marrow transplant survivor study
TLDR
Although prevalence of conception is diminished after HCT, if pregnancy does occur, outcome is likely to be favorable and patients should be counseled prior to transplant regarding strategies to preserve fertility.
Pregnancy after hematopoietic cell transplantation: a report from the late effects working committee of the Center for International Blood and Marrow Transplant Research (CIBMTR).
  • A. Loren, E. Chow, N. Majhail
  • Medicine, Biology
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
  • 2011
Fertility after allogeneic haematopoietic stem cell transplantation in childhood and adolescence
TLDR
In light of the significant proportion of HSCT patients reviewed with impaired fertility, fertility conservation procedures should be considered for all patients undergoing HSCT, particularly those receiving TBI or BU-based preparative regimens.
Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients
TLDR
Recovery of normal ovarian function and a viable pregnancy is a realistic but relatively rare possibility even in Fanconi anemia patients following hematopoietic stem cell transplantation, as well as Mechanisms of fertility recovery are discussed.
Uptake and outcome of assisted reproductive techniques in long-term survivors of SCT
TLDR
In conclusion, uptake of gamete/embryo storage is high when offered and collected material is used frequently and the value of prolonged cryostorage is highlighted.
Successful pregnancy following busulfan and cyclophosphamide conditioning and allogeneic bone marrow transplantation for chronic myeloid leukemia.
Menstrual patterns, fertility and main pregnancy outcomes after allogeneic haematopoietic stem cell transplantation
TLDR
This study confirms the crucial role of full dose total body irradiation (TBI) and age on menses recovery and fertility after haematopoietic stem cell transplantation (HSCT) and the impact of severe cGVHD remains unclear.
Endocrine late effects after bone marrow transplant
TLDR
Bone marrow transplantation has increased significantly in the last decade and encompasses allogeneic and autologous transplantation of stem cells from bone marrow, peripheral blood and umbilical cord blood, but this success story in transplantation medicine has resulted in significant endocrine late effects both in children and adults.
Long-term follow-up of fertility and pregnancy in autoimmune diseases after autologous haematopoietic stem cell transplantation
TLDR
Pre-HSCT treatment and patients’ age seem to have higher impact on long-term fertility status than HSCT itself, and AD patients undergoing HSCT offers the opportunity to conceive during treatment-free remissions with favourable pregnancy outcomes.
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References

SHOWING 1-10 OF 23 REFERENCES
Pregnancy after bone marrow transplantation.
  • S. Gulati, C. V. Van Poznak
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1998
TLDR
The issue of counseling BMT patients about fertility, pregnancy complications, and potential birth defects is becoming increasingly complex and warrants further investigation.
Early high dose chemotherapy intensification with autologous bone marrow transplantation in lymphoma associated with retention of fertility and normal pregnancies in females. Scotland and Newcastle Lymphoma Group, UK.
TLDR
The Newcastle/SNLG autotransplant differs from the approach in many EBMTR centres in that it usesMelphalan or melphalan/etoposide alone instead of the more common four drug containing regimens and yet sustained complete remission rates indicate that the non-ablative approach is equally effective as more aggressive regimens on the disease with the huge advantage of preserved fertility in females.
Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation.
TLDR
Pregnancies among all women who received a marrow transplant are likely to be accompanied by preterm labor and delivery of LBW or VLBW babies who do not seem to be at an increased risk of congenital anomalies, but determination of possible adverse effects of parental exposure to high-dose alkylating agents with or without TBI on children born posttransplant requires longer, additional follow-up.
Long-term outcome after marrow transplantation for severe aplastic anemia.
TLDR
In conclusion, marrow transplantation in patients with aplastic anemia established long-term normal hematopoiesis and the majority of patients who survived beyond 2 years returned to a fully functional life.
Melphalan alone prior to allogeneic bone marrow transplantation from HLA-identical sibling donors for hematologic malignancies: alloengraftment with potential preservation of fertility in women.
TLDR
It is concluded that pre-transplant conditioning with melphalan alone permits alloengraftment of marrow from HLA-identical siblings, and may preserve fertility better than other regimens in some women.
Successful pregnancy after allogeneic bone marrow transplant with embryos isolated before transplant.
  • J. Lipton, M. Virro, H. Solow
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1997
TLDR
The experience offers a fertility-salvaging technique to some women after cytotoxic therapy, where time permits ovarian hyperstimulation before the need for definitive myeloblative therapy of their malignancy, and where the risk of subsequent infertility is high.
Successful pregnancy after bone marrow transplantation for thalassaemia.
TLDR
The first patient transplanted for thalassaemia, after ablative therapy with busulfan and cyclophosphamide, who, despite late pubertal maturation, became pregnant and delivered a full-term, normal infant is reported on.
Germ cell failure and Leydig cell insufficiency in post-pubertal males after autologous bone marrow transplantation with BEAM for lymphoma.
TLDR
It is indicated that short-term chemoradiotherapy causes profound damage to the germ cell compartment of the testis, with less severeDamage to the Leydig cells, but no overt injury to the anterior pituitary gland.
Full-term pregnancy with embryos from donated oocytes in a 36-year-old woman allografted for chronic myeloid leukemia.
We report the first case of full-term pregnancy arising from donated oocytes in a 36-year-old woman with chronic myeloid leukemia (CML), 6 years after allogeneic bone marrow transplantation (BMT)
Prospective study of pituitary-gonadal function to evaluate short-term effects of ablative chemotherapy or total body irradiation with autologous or allogenic marrow transplantation in post-menarcheal female patients.
TLDR
The data indicate that the ovary suffers an acute insult during short-term chemotherapy but the anterior pituitary gland retains its trophic hormone reserve and secretory capacity.
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