Pregnancy outcome in patients with inflammatory bowel disease treated with thiopurines: cohort from the CESAME Study

@article{Coelho2010PregnancyOI,
  title={Pregnancy outcome in patients with inflammatory bowel disease treated with thiopurines: cohort from the CESAME Study},
  author={Jessica Coelho and Laurent Beaugerie and J F Colombel and Xavier H{\'e}buterne and {\'E}ric Lerebours and Marc L{\'e}mann and Philippe Baumer and Jacques Cosnes and Arnaud Bourreille and Jean Pierre Gendre and Philippe Seksik and Antoine Blain and Etienne Henry Metman and Andr{\'e}e Nisard and Guillaume Cadiot and Michel Veyrac and Benoit Coffin and Xavier Dray and Fabrice Carrat and Philippe Marteau},
  journal={Gut},
  year={2010},
  volume={60},
  pages={198 - 203}
}
Background and aims Few studies have been conducted addressing the safety of thiopurine treatment in pregnant women with inflammatory bowel disease (IBD). The aim of this study was to evaluate the pregnancy outcome of women with IBD who have been exposed to thiopurines. Methods 215 pregnancies in 204 women were registered and documented in the CESAME cohort between May 2004 and October 2007. Physicians documented the following information from the women: last menstrual date, delivery term… 
Pregnancy outcomes in women with inflammatory bowel disease following exposure to thiopurines and antitumor necrosis factor drugs
TLDR
A benefit–risk ratio should be considered in prescribing or continuing medicinal therapy during pregnancy of IBD patients and congenital abnormalities were increased significantly in thiopurine-exposed group in comparison with control group who did not receive any medicine for IBD treatment.
Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease
TLDR
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TLDR
Data from a meta-analysis of all original human studies reporting outcomes in pregnancy in patients receiving thiopurines for IBD treatment in pregnancy provide support for thiopURines having a minimal risk, if any, to the fetus.
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TLDR
This relatively small case series supports safe use of TG in pregnant IBD patients, and consideration should be given to the indication and continuation of TG during pregnancy.
Use of Thiopurines During Conception and Pregnancy Is Not Associated With Adverse Pregnancy Outcomes or Health of Infants at One Year in a Prospective Study
Maternal and fetal outcomes in pregnant Japanese women with inflammatory bowel disease: our experience with a series of 23 cases
TLDR
Assessment of patients with IBD during pregnancy confirmed that even if the disease flares up during pregnancy, good pregnancy outcomes can be achieved with an optimal intensification of the patient's treatment.
Thiopurines during pregnancy in inflammatory bowel disease: is there a risk for the (unborn) child?
Conventional thiopurines, being azathioprine (AZA) and mercaptopurine (MP) are considered the cornerstone of immunosuppressive maintenance therapy in patients with inflammatory bowel disease (IBD)
CESAME Substudy on Thiopurines in Pregnancy: Is This the Baby We Were Waiting For?
TLDR
The study by Coelho et al recently published in Gut aimed at evaluating pregnancy outcomes in female IBD patients treated with thiopurines, finding that there was no increase in the risks of congenital abnormalities.
Safety of Thiopurines and Anti-TNF-α Drugs During Pregnancy in Patients With Inflammatory Bowel Disease
TLDR
The treatment with thiopurines and anti-TNF-α drugs does not seem to increase the risk of complications during pregnancy and does seem to be safe for the newborn.
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