Pregnancy outcome and live birth after IVF and ICSI according to embryo quality

Abstract

Purpose: The pregnancy outcome and the chances of birth were assessed according to embryo quality after IVF or ICSI. Methods: The implantation rate (IR), the loss of gestational sacs rate (LGSR), and birth rate (BR) were determined according to the cleavage stage and the integrity of blastomeres after day-2 homogeneous embryo transfers (n = 1812). Results: The LGSR was higher after transfers of 2–3-cell or 5–6-cell embryos and was significantly increased when more than 20% of the embryo volume was fragmented in 4-cell embryos. After transfers of 4-cell embryos without fragmentation, the BR was significantly higher than the BR after transfers of 4-cell embryos with 1–20% fragmentation (16.6% vs 13.1%). The difference was the consequence of a higher IR (20.4% vs 17.3%) but also of a lower LGSR (18.9% vs 24.2%). Conclusions: Not only implantation and the ability to give a pregnancy, but also the capacity to give a live birth are dependent on the embryo quality.

DOI: 10.1007/s10815-007-9115-z

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@article{Fauque2007PregnancyOA, title={Pregnancy outcome and live birth after IVF and ICSI according to embryo quality}, author={Patricia Fauque and Roger Dominique Leandri and Françoise Merlet and J M Juillard and Sylvie Epelboin and Juliette Guibert and Pierre Jouannet and Catherine Patrat}, journal={Journal of Assisted Reproduction and Genetics}, year={2007}, volume={24}, pages={159-165} }