Pregnancy-induced thymic involution is associated with suppression of chemokines essential for T-lymphoid progenitor homing.

@article{Laan2016PregnancyinducedTI,
  title={Pregnancy-induced thymic involution is associated with suppression of chemokines essential for T-lymphoid progenitor homing.},
  author={Martti Laan and Uku Haljasorg and Kai Kisand and Andres Salumets and P{\"a}rt Peterson},
  journal={European journal of immunology},
  year={2016},
  volume={46 8},
  pages={2008-17}
}
During normal pregnancy, the thymus undergoes a severe reduction in size and thymocyte output, which may contribute to maternal-fetal tolerance. It is presently unknown whether the pregnancy-induced thymic involution also affects nonlymphoid thymic cell populations and whether these changes in stromal cells play a role in the reduction in thymocyte numbers. Here, we characterize the changes in thymic lymphoid and nonlymphoid cells and show that pregnancy results in a reduction of all major… CONTINUE READING

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