Pregnancy-induced changes in thyroid function: role of human chorionic gonadotropin as putative regulator of maternal thyroid.

@article{Ballabio1991PregnancyinducedCI,
  title={Pregnancy-induced changes in thyroid function: role of human chorionic gonadotropin as putative regulator of maternal thyroid.},
  author={Mauro Ballabio and M Poshychinda and R P Ekins},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1991},
  volume={73 4},
  pages={824-31}
}
Marked changes in maternal thyroid activity occur in pregnancy. It has been suggested that hCG may stimulate maternal T4 secretion, given its in vitro thyrotropic activity ascribed to a significant degree of structural homology with TSH. In a longitudinal study of 32 normal pregnant women, we attempted to clarify the functional activity of the thyroid in early and late pregnancy and the possibility of a nonpituitary control on the thyroid. Total T4 and T4-binding globulin levels were increased… CONTINUE READING

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