Pregnancy in cystic fibrosis. Fetal and maternal outcome.

@article{Gilljam2000PregnancyIC,
  title={Pregnancy in cystic fibrosis. Fetal and maternal outcome.},
  author={Marita Gilljam and Maria-Christina Antoniou and J. C. Shin and Annie Dupuis and M. L. Corey and Diana Elizabeth Tullis},
  journal={Chest},
  year={2000},
  volume={118 1},
  pages={
          85-91
        }
}
OBJECTIVE To assess the effect of pregnancy on pulmonary function and survival in women with cystic fibrosis (CF) and to assess the fetal outcome. DESIGN Cohort study. The data analyzed were collected from the Toronto CF database, chart review, and patient questionnaire. SETTING Tertiary-care center. PATIENTS All women with CF who, at the time of diagnosis or pregnancy, attended the Toronto Cystic Fibrosis Clinics between 1961 and 1998. RESULTS From 1963 to 1998, there were 92… 
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135 Citations
Highly Influential Citations
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Background Citations
9
Methods Citations
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Results Citations
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135 Citations

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Citation Type

Impact of pregnancy on women with cystic fibrosis.
TLDR
These findings suggest that, over the same time period, women with CF who become pregnant experienced similar respiratory and health trends as nonpregnant women, however, pregnant women use a greater number of therapies and receive more intense monitoring of their health.
Current pregnancy outcomes in women with cystic fibrosis.
TLDR
With careful multidisciplinary antenatal and intrapartum management, successful outcomes have been obtained in this group of women with CF with varied pre-pregnancy lung function.
The effect of pregnancy on survival in women with cystic fibrosis.
TLDR
Women with cystic fibrosis who became pregnant were initially healthier and had better 10-year survival rates than women with CF who did not become pregnant, and pregnancy was not harmful in any subgroup including patients with FEV(1) < 40% of predicted or diabetes mellitus.
Maternal and Perinatal Outcomes in Pregnant Women with Cystic Fibrosis.
TLDR
Pregnant women with cystic fibrosis and severe lung impairment did not present an association with spontaneous prematurity, fetal growth restriction or fetal demise, and pregnancies of women with CF are frequently complicated by REs, and this population may require hospital admission during the course of the pregnancy.
Maternal and perinatal outcomes of pregnancies in women with cystic fibrosis--A single centre case-control study.
TLDR
Multidisciplinary care of pregnancy in women with cystic fibrosis resulted in maternal and perinatal outcomes similar to those found in women in the general population.
Aggressive prenatal care results in successful fetal outcomes in CF women.
  • E. Cheng, C. Goss, +4 authors M. L. Aitken
  • Medicine
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
  • 2006
TLDR
CF women with severe pulmonary impairment tend to have lower weight babies but it remains difficult to determine prospectively which CF women will tolerate pregnancy well.
Pregnancy outcome in women with cystic fibrosis and poor pulmonary function.
TLDR
Poor pre-gestational pulmonary function in women with cystic fibrosis was associated with a higher rate of cesarean section and a clinically significant impact on fetal growth, but was not associated with more important pulmonary and nutritional decline over the study period.
Cystic fibrosis and pregnancy in the modern era: a case control study.
TLDR
Pregnancy does not lead to immediate or medium-term adverse effects for CF patients and significant predictors of decline included higher pre-pregnancy lung function and pancreatic insufficiency.
Two successful pregnancies in a woman affected by cystic fibrosis: case report and review of the literature
TLDR
Pre‐pregnant lung function as well as lung function deterioration, CF‐related diabetes mellitus and weight gain in pregnancy, are parameters to consider in the counseling about the outcome of pregnancy.
Medical and obstetric complications among pregnant women with cystic fibrosis.
TLDR
Pregnant women with CF are more likely to die, require mechanical ventilation, and have infectious complications compared with women without CF, although the absolute risks are low and these events are relatively rare.
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References

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TLDR
Pregnancy has little adverse effect on patients with stable CF, but poor outcomes can occur in individuals with more advanced disease.
Outcome of pregnancy in women with cystic fibrosis.
TLDR
Pregnancy was well tolerated by most mothers with cystic fibrosis although those with moderate to severe lung disease (%FEV1 < 60%) before pregnancy fared worse, producing preterm infants and suffering increased loss of lung function and mortality compared with mildly affected mothers.
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TLDR
Premature labour and delivery remain a significant risk for pregnant women with CF, contributing to a high rate of perinatal death and deteriorating pulmonary function.
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TLDR
Maternity patients with cystic fibrosis who had 13 completed pregnancies between 1975 and 1995 were retrospectively reviewed to assess the changes in spirometry and body mass index (BMI) during pregnancy and maternal and neonatal complications and outcomes.
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TLDR
All of the 11 living infants in the present study were normal and showed no stigmata of cystic fibrosis.
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TLDR
Pregnancy is contraindicated for CF women with raised PaCO2, and SaO2 of 90%, and cor pulmonale, and a CF woman must consider timing, family support, and genetics of the father when planning a pregnancy.
Pregnancy and Cystic Fibrosis
TLDR
It is found that pregnancy can be tolerated by the majority of cystic fibrosis patients, particularly those who are pancreatic- sufficient, and had little effect on their pulmonary and nutritional status.
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TLDR
Important premises to the management of pregnancy and delivery in cystic fibrosis have to be adequate pre- and postpartal diagnosis and therapy of pulmonary and/or cardiac disease and careful management of nutrition, control of pancreatic insufficiency and electrolyte balance.
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TLDR
A study from the Cystic Fibrosis Foundation National Patient Registry is to identify specific indices for quantitating risks related to pregnancy for women with CF so that their physicians, with these data in hand, will be better able to counsel them.
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