Pregnancy immunogenetics: NK cell education in the womb?

  title={Pregnancy immunogenetics: NK cell education in the womb?},
  author={Peter R Parham and Lisbeth A. Guethlein},
  journal={The Journal of clinical investigation},
  volume={120 11},
During embryo implantation and initiation of pregnancy, uterine NK (uNK) cells engage invasive fetal trophoblasts to remodel vessels that conduct blood to the placenta. This partnership, involving uNK cell receptors that recognize HLA-C ligands on trophoblasts, varies the course of human pregnancy because the genes for both receptors and ligands are extraordinarily diverse. Several pregnancy disorders are attributed to insufficient trophoblast invasion and the limitation it imposes on human… CONTINUE READING
Highly Cited
This paper has 791 citations. REVIEW CITATIONS

1 Figure or Table



Citations per Year

791 Citations

Semantic Scholar estimates that this publication has 791 citations based on the available data.

See our FAQ for additional information.