Pregnancy block by MHC class I peptides is mediated via the production of inositol 1,4,5-trisphosphate in the mouse vomeronasal organ.

@article{Thompson2007PregnancyBB,
  title={Pregnancy block by MHC class I peptides is mediated via the production of inositol 1,4,5-trisphosphate in the mouse vomeronasal organ.},
  author={Roger N Thompson and Ronald K McMillon and Audrey Napier and Kennedy S. Wekesa},
  journal={The Journal of experimental biology},
  year={2007},
  volume={210 Pt 8},
  pages={1406-12}
}
The vomeronasal organ (VNO) has evolved to link an animal's behavior to its environment in a highly species-specific fashion. In mice, it is thought to be the primary sensory system responsible for the detection of pheromones. Pheromones regulate a variety of responses including mate recognition in the context of selective pregnancy failure. MHC (major histocompatibility complex) class I peptides have been identified as compounds that elicit the pregnancy block effect via the VNO. However, the… CONTINUE READING
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