Pregnancy-associated plasma protein A: a possible marker in the classification and prenatal diagnosis of Cornelia de Lange syndrome.

@article{Westergaard1983PregnancyassociatedPP,
  title={Pregnancy-associated plasma protein A: a possible marker in the classification and prenatal diagnosis of Cornelia de Lange syndrome.},
  author={Jes Grabow Westergaard and John Chemnitz and B\orge Teisner and Henning Poulsen and L Ipsen and Brygida Beck and Jurgis Gedis Grudzinskas},
  journal={Prenatal diagnosis},
  year={1983},
  volume={3 3},
  pages={225-32}
}
The concentration of human platelet lactogen (hPL), pregnancy specific beta-1 glycoprotein (SP-1) and pregnancy-associated plasma protein A (PAPP-A) were analysed in consecutive serum samples from a patient who gave birth to a child with Cornelia de Lange syndrome. HPL and SP-1 were present in normal concentrations from week 20 to week 35 of gestation whereas PAPP-A could not be detected in any of the samples examined. Immunohistochemical examination of two placentae from Cornelia de Lange… CONTINUE READING

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