Pregnancy-associated breast cancer and metastasis

@article{Schedin2006PregnancyassociatedBC,
  title={Pregnancy-associated breast cancer and metastasis},
  author={Pepper J. Schedin},
  journal={Nature Reviews Cancer},
  year={2006},
  volume={6},
  pages={281-291}
}
  • P. Schedin
  • Published 1 April 2006
  • Medicine, Biology
  • Nature Reviews Cancer
Pregnancy-associated breast cancer, which has a poor prognosis, is often overlooked by clinicians and researchers alike. With the trend towards delayed child-bearing, an increase in the occurrence of breast cancer complicated by pregnancy is anticipated. The mechanisms that have been proposed to account for this poor prognosis, including increased hormone exposure, might not contribute significantly to the observed increase in metastasis seen in these patients. Instead, the mammary… 
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391 Citations
Highly Influential Citations
28
Background Citations
193
Methods Citations
6
Results Citations
9

391 Citations

Breast cancer, placenta and pregnancy.

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The involution-hypothesis, which states that the wound healing microenvironment of the involuting gland is tumor promotional, is proposed and is a novel target for breast cancer treatment and prevention.

Prognosis of pregnancy-associated breast cancer

Current evidence suggests that breast cancer diagnosed during pregnancy is a different entity from that diagnosed postpartum, both in terms of prognosis and biology, and future research and discussion should separate these two into distinct groups.

Understanding heterogeneity in pregnancy-associated breast cancer

  • T. M. Nair
  • Biology, Medicine
    2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
  • 2015
Analysis of data from the first large scale study to identify molecular signatures associated with pregnancy associated breast cancer reveals features that are unique between classes, as well as point to the importance of understanding heterogeneity within the same class.

Pregnancy-Associated Breast Cancer: A Multidisciplinary Approach.

Pregnancy and breast cancer : risk patterns, tumour characteristics and prognosis

The results showed that a family history of BC did not affect the risk pattern around pregnancy and up to 10 years post-delivery, indicating that pregnancy-related exposures do not interact with the familial pre-disposition for BC in these women.

Pregnancy-Associ ated Breast Cancer

Analysis of data from the first large scale study to identify molecular signatures associated with pregnancy associated breast cancer reveals features that are unique between classes, as well as point to the importance of understanding heterogeneity within the same class.
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