Pregnancy-associated breast cancer and metastasis

  title={Pregnancy-associated breast cancer and metastasis},
  author={Pepper J. Schedin},
  journal={Nature Reviews Cancer},
  • P. Schedin
  • Published 1 April 2006
  • Medicine, Biology
  • Nature Reviews Cancer
Pregnancy-associated breast cancer, which has a poor prognosis, is often overlooked by clinicians and researchers alike. With the trend towards delayed child-bearing, an increase in the occurrence of breast cancer complicated by pregnancy is anticipated. The mechanisms that have been proposed to account for this poor prognosis, including increased hormone exposure, might not contribute significantly to the observed increase in metastasis seen in these patients. Instead, the mammary… 

Breast cancer, placenta and pregnancy.

Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype

Recent progress in understanding the development of breast cancer during pregnancy and their unique subtype of triple negative which is the hallmark of this type of breast Cancer is reviewed.

Surgery on breast cancer in pregnancy

The aim of this literature review is to analyze the main topics regarding surgical treatment of patients diagnosed with breast cancer in pregnancy: anesthesia and maternal-fetal monitoring, type of breast surgery, immediate breast reconstruction after radical surgery and management of the axilla.

Pregnancy-associated breast cancer.

The frequency of pregnancy-associated breast cancer, a rare but serious occurrence, may increase in light of the secular trends for lower parity in general and for older age at first full-term

Macrophages in Breast Cancer: Do Involution Macrophages Account for the Poor Prognosis of Pregnancy-Associated Breast Cancer?

The involution-hypothesis, which states that the wound healing microenvironment of the involuting gland is tumor promotional, is proposed and is a novel target for breast cancer treatment and prevention.

Prognosis of pregnancy-associated breast cancer

Current evidence suggests that breast cancer diagnosed during pregnancy is a different entity from that diagnosed postpartum, both in terms of prognosis and biology, and future research and discussion should separate these two into distinct groups.

Understanding heterogeneity in pregnancy-associated breast cancer

  • T. M. Nair
  • Biology, Medicine
    2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
  • 2015
Analysis of data from the first large scale study to identify molecular signatures associated with pregnancy associated breast cancer reveals features that are unique between classes, as well as point to the importance of understanding heterogeneity within the same class.

Pregnancy and breast cancer : risk patterns, tumour characteristics and prognosis

The results showed that a family history of BC did not affect the risk pattern around pregnancy and up to 10 years post-delivery, indicating that pregnancy-related exposures do not interact with the familial pre-disposition for BC in these women.

Pregnancy-Associ ated Breast Cancer

Analysis of data from the first large scale study to identify molecular signatures associated with pregnancy associated breast cancer reveals features that are unique between classes, as well as point to the importance of understanding heterogeneity within the same class.



Parity and breast cancer: evidence of a dual effect.

It is concluded that reproductive history influences not only the risk of breast cancer but also the latent interval of a proportion of breast carcinomas.

Breast cancer in pregnancy: a literature review.

Physicians should perform a thorough breast examination at the first prenatal visit and maintain a high index of suspicion for cancer, as pregnancy-associated cancers tend to occur at a later stage and be estrogen receptor-negative.

Differentiation of the mammary gland and susceptibility to carcinogenesis

Induction of mammary cancer in rats by administration of the chemical carcinogen 7, 12-dimethylbenz(a)anthracene reveals that the same factors influencing human breast cancer risk also affect the susceptibility of the rat mammary gland to the chemicalcar carcinogen.

Effect of Progesterone Receptor A Predominance on Breast Cancer Cell Migration into Bone Marrow Fibroblasts

Testing the hypothesis that predominance of PRA affects the interaction of breast cancer cells with a physiologically relevant stromal tissue, bone marrow stroma has shown that PRA predominance has a striking functional effect on breast cancer cell migration intoStromal layers.

Etiology of human breast cancer: a review.

The hypothesis that breast cancer risk is related to estrogen metabolism during the first few years after menarche is the hypothesis most compatible with all the major epidemiological features of the disease and is virtually the only acceptable explanation.

Overall survival from breast cancer in women pregnant or lactating at or after diagnosis

No significant differences in survival were found between those women who had pregnancies subsequent to diagnosis of breast cancer and breast cancer patients who did not become pregnant; however, survival was similar between pregnant and non‐pregnant patients when these variables were taken into account.

The relation of reproductive factors to mortality from breast cancer.

  • J. DalingK. MaloneD. DoodyB. AndersonP. Porter
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2002
Evidence is provided that reproductive factors influence the biological behavior of breast cancer in young women and prognosis and Clinicians need to be aware that women who have delivered a child in < 2 years before diagnosis are at increased risk of having tumors with especially adverse prognostic profiles and have a poorer survival rate than women who are nulliparous or whose last birth was some years in the past.

Breast cancer and pregnancy: a diagnostic and management dilemma

Background:  The purpose of the present paper was to review the current knowledge of pregnancy concurrent with a diagnosis of breast cancer, and how best to manage this group of women and those

Breast Cancer Patients with Progesterone Receptor PR-A-Rich Tumors Have Poorer Disease-Free Survival Rates

Knowing the PR-A:PR-B ratio may identify a subgroup of ER-positive/PR-positive patients with node-positive breast cancer that benefit poorly from endocrine therapy, and may affect tamoxifen response in breast cancers.