Pregnancy and the Ehlers–Danlos syndrome: a retrospective study in a Dutch population

@article{Lind2002PregnancyAT,
  title={Pregnancy and the Ehlers–Danlos syndrome: a retrospective study in a Dutch population},
  author={John Lind and Henk C. S. Wallenburg},
  journal={Acta Obstetricia et Gynecologica Scandinavica},
  year={2002},
  volume={81}
}
Background.  The study was carried out to assess the course and outcome of pregnancies in women with the Ehlers–Danlos syndrome, with the aim of developing guidelines for assessment of risk and counseling, and for providing optimum medical and obstetric care. 

Ehlers–Danlos syndrome in the parturient: an uncommon disorder–common dilemma in the delivery room

Because of multi-organ involvement and the varied presentations of this disease, no uniform obstetric and anesthetic recommendations regarding the peripartum care of these parturients can be made.

Ehlers-Danlos Syndrome in Pregnancy: A Review.

Obstetrics and gynecology in Ehlers‐Danlos syndrome: A brief review and update

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Having a known diagnosis of Ehlers‐Danlos syndromes allows anticipatory planning, resulting in lower morbidity from hemorrhage and tissue injury, and with continued progress in understanding the underlying mechanisms, more effective treatments can be developed.

Pregnancy outcome in joint hypermobility syndrome and Ehlers–Danlos syndrome

An increased risk of preterm birth in women with joint hypermobility syndrome or Ehlers–Danlos syndrome is suspected.

Pregnancy and Delivery in Ehlers-Danlos Syndrome (Hypermobility Type): Review of the Literature

Cesarean section was deemed the most appropriate delivery method in this patient due to the possible complications including risk of joint dislocation and pain morbidity, and good maternal and neonatal outcomes were achieved.

A case report of obstetrical management of a pregnancy with hypermobile Ehlers–Danlos syndrome and literature review

The obstetric management of a patient with EDS hypermobility type and compares it to other studies in the literature is discussed.

Gynecologic and obstetric impact of the ehlers-danlos syndrome : clues from scrutinizing dermal ultrastructural alterations

The Ehlers-Danlos syndrome is a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective tissues.

Successful pregnancy outcome in Ehlers–Danlos syndrome, vascular type

  • M. PalmquistJ. PappasB. PetrikovskyK. BlakemoreD. Roshan
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2009
There is no consensus in the literature on the timing and mode of delivery for pregnant women with vascular EDS, but the management undertaken in the patient may assist others in optimizing the perinatal outcome in other women who elect to continue their pregnancy despite the risks.

Anesthesia for a Cesarean Section in a Patient with Ehlers-Danlos Syndrome - A case report -

A case of a patient with EDS of an unknown type who successfully underwent an emergency cesarean section under general anesthesia is reported.

Fatal Bleeding following Delivery: A Manifestation of the Vascular Type of Ehlers-Danlos’ Syndrome

Early recognition is crucial to avoid maternal mortality due to this genetic disorder, and this case report reports a 31-year-old primipara who died from a rupture of the right subclavian artery.
...

References

SHOWING 1-10 OF 28 REFERENCES

EHLERS‐DANLOS SYNDROME TYPE III IN PREGNANCY

During the pregnancy, the patient suffered from increasing joint laxity, requiring prolonged bed rest and traction, and early delivery by cesarean section was ultimately performed to relieve her symptoms.

Ehlers-Danlos syndrome and pregnancy: association of type IV disease with maternal death.

A maternal death with type IV is reported, and the literature for obstetric complications of the syndrome by type is reviewed, finding recommendations for managing pregnancies complicated by EDS.

Ehlers-Danlos syndrome type IV. Clinical and molecular aspects and guidelines for diagnosis and management.

The clinical, biochemical and molecular characteristics of Ehlers-Danlos syndrome type IV are reviewed. The numerous clinical manifestations result from the generalized and excessive tissue fragility

Ehlers-Danlos syndrome during pregnancy: a case report and review of the literature.

It is hoped that in future reports of pregnancy in association with Ehlers-Danlos syndrome that patients are classified according to type so that prognosis, particularly in the mitis form, can be more accurately assessed.

Abnormal presentation in labor and fetal growth of affected infants with type III Ehlers-Danlos syndrome.

A survey of patients with Ehlers-Danlos syndrome.

A survey of 151 EDS patients showed a high percentage of the patients were classified as having Types I through IV, and Bracing and fusion appear to be the most commonly used methods of orthopedic care.

PREGNANCY COMPLICATIONS IN TYPE IV EHLERS-DANLOS SYNDROME

Obstetric and gynecologic dysfunction in the Ehlers-Danlos syndrome.

In this largest series of pregnancies with EDS, it is found relatively high rates of abortion, preterm delivery, pregnancy-related bleeding and stillbirth, and women with E DS also seem to have high frequency of anovulation, vaginal infections, abnormal cytologic smears and dyspareunia.

Ehlers‐Danlos syndromes: Revised nosology, Villefranche, 1997

This work proposes a revision of the classification of the Ehlers-Danlos syndromes based primarily on the cause of each type based on major and minor diagnostic criteria defined for each type and complemented whenever possible with laboratory findings.

Large kindred with Ehlers-Danlos syndrome type IV due to a point mutation (G571S) in the COL3A1 gene of type III procollagen: low risk of pregnancy complications and unexpected longevity in some affected relatives.

Longevity is longer than that seen in many families and there is less pregnancy-associated morbidity or mortality than in some families, which suggests that some clinical aspects of EDS type IV may be related to the nature of the mutation and its effect on the behavior of the protein.