Pregnancy and sarcoidosis: an insight into the pathogenesis of hypercalciuria.

@article{Subramanian2004PregnancyAS,
  title={Pregnancy and sarcoidosis: an insight into the pathogenesis of hypercalciuria.},
  author={P. Subramanian and Hithaishi Chinthalapalli and M. Krishnan and S. Tarlo and T. Lobbedez and M. Pineda and D. Oreopoulos},
  journal={Chest},
  year={2004},
  volume={126 3},
  pages={
          995-8
        }
}
Hypercalciuria with or without hypercalcemia is a well-known complication of sarcoidosis, the pathogenesis of which is not fully understood. Pregnancy is associated with physiologic alterations in calcium metabolism. These changes can further alter the derangement of calcium metabolism that occurs in sarcoidosis, if the two conditions coexist. We had the opportunity to study prospectively the changes in serum and urine calcium along with all the hormonal changes that occur during pregnancy in a… Expand
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An Educational Resource StAtE of thE ARt PAPER on SARcoidoSiS provided by the thoracic Society of Australia and new Zealand
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References

SHOWING 1-10 OF 32 REFERENCES
Calcium metabolism in sarcoidosis and its clinical implications.
TLDR
The mechanisms of abnormal calcium metabolism in sarcoidosis need to be understood when treating hypercalcaemia, hypercalcuria and corticosteroid-induced osteoporosis and studies are required to determine if the currently available therapies for osteopOrosis are safe and effective in sar coidosis. Expand
Different Mechanisms of Hypercalciuria in Sarcoidosis
TLDR
Interest was stimulated by recent observations which disclosed high serum levels of 1,25-dihydroxyvitamin D, (1,25-(OH),-D,) in this disease and culminated when a coherent body of clinical and experimental data demonstrated that, in patients with sarcoidosis, the production of this dihydroxylated metabolite of vitamin D, can be e-trarenal. Expand
Calcium metabolism in sarcoidosis. A follow-up study with respect to parathyroid hormone and vitamin D metabolites.
TLDR
The results of follow-up of untreated and treated patients support the suggestion that 1,25-(OH)2D may reflect the systemic granulomatous process (disease activity?) and the mechanism for abnormal calcium metabolism remains very complex and may not result from increased serum levels of 1, 25-(OH]2D alone. Expand
1, 25-DIHYDROXYCHOLECALCIFEROL IN THE PATHOGENESIS OF THE HYPERCALCÆMIA OF SARCOIDOSIS
TLDR
It is shown for the first time that hypercalcaemia in sarcoidosis is associated with abnormally high circulating concentrations of 1, 25-dihydroxycholecalciferol, probably as a result of overproduction of this, the hormonal form of vitamin D. Expand
Renal involvement in sarcoidosis
TLDR
Histopathological changes specific of sarcoidosis are related to an abnormal amount of serum gammaglobulins and calciuria exceeding 200 mg in 24 hr, which seem to be the best tests of involvement by the disease. Expand
Parathyroid function in sarcoidosis.
TLDR
The data indicate that most patients with sarcoidosis have functional hypoparathyroidism, which fits well with the recognized abnormalities of calcium metabolism in sarCOidosis, since excessiv... Expand
Sarcoidosis and pregnancy: a review with results of a retrospective survey
  • O. Selroos
  • Medicine
  • Journal of internal medicine
  • 1990
TLDR
Pregnancy appears to have an ameliorating effect on sarcoidosis during the prenatal period, but that this benefit is frequently lost after delivery, and the available information indicates that for patients whose chest radiographic changes have changed. Expand
Calcium and phosphate metabolism in sarcoidosis with particular reference to parathyroid function.
TLDR
Investigation of patients with sarcoidosis for abnormalities of calcium and phosphate metabolism with particular reference to parathyroid function found no abnormality of serum calcium, phosphate, creatinine or alkaline phosphatase, and serum levels of 25-OH cholecalciferol were normal. Expand
Ionized calcium and 1,25-dihydroxyvitamin D concentration in serum of patients with sarcoidosis.
TLDR
A disease-related alteration in calcium metabolism was seen in about 40% of patients with sarcoidosis, and 1,25-dihydroxyvitamin D probably plays a crucial role in this abnormality. Expand
Sarcoidosis and pregnancy.
TLDR
Cases of sarcoidosis and pregnancy during a ten-year period at Downstate Medical Center were reviewed, with factors indicating a poor prognosis included parenchymal lesions on chest x-ray, advanced roentgenologic staging, advanced maternal age, low inflammatory activity, requirement for drugs other than steroids, and presence of extrapulmonary sarcoIDosis. Expand
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