Pregnancy and sarcoidosis: an insight into the pathogenesis of hypercalciuria.

  title={Pregnancy and sarcoidosis: an insight into the pathogenesis of hypercalciuria.},
  author={P. Subramanian and Hithaishi Chinthalapalli and M. Krishnan and S. Tarlo and T. Lobbedez and M. Pineda and D. Oreopoulos},
  volume={126 3},
Hypercalciuria with or without hypercalcemia is a well-known complication of sarcoidosis, the pathogenesis of which is not fully understood. Pregnancy is associated with physiologic alterations in calcium metabolism. These changes can further alter the derangement of calcium metabolism that occurs in sarcoidosis, if the two conditions coexist. We had the opportunity to study prospectively the changes in serum and urine calcium along with all the hormonal changes that occur during pregnancy in a… Expand
Sarcoidosis presenting with severe hypocalcaemia
Di George syndrome, is a dysmorphic disorder characterised by aplasia/hypoplasia of thymus and parathyroid glands in addition to aortic arch anamolies and facial dysmorphia, and after commencing appropriate treatment this lady made excellent recovary. Expand
Two cases of sarcoidosis with facial skin lesions appearing after delivery
The cutaneous and ocular lesions were improved by 10 mg/day of prednisolone and did not recur after treatment cessation, and the skin biopsy showed non-caseating epithelioid cell granulomas in the dermis. Expand
Importancia de los polimorfismos de la ciclooxigenasa-2 en la presentación clínica de la sarcoidosis.
The results suggest that allele C carriers of COX2.3050G>C polymorphism are associated with the systemic manifestations of sarcoidosis. Expand
Herpes zoster ophthalmicus with severe ocular complications
In the two cases, the cutaneous lesions improved after treatment and there was no recurrence after treatment cessation, and patients showing the appearance or exacerbation of sarcoidosis after childbirth should be carefully monitored. Expand
Association of the 3050G>C polymorphism in the cyclooxygenase 2 gene with systemic sarcoidosis.
The results indicate for the first time that the C allele of the COX2.3050G>C polymorphism is associated with systemic sarcoidosis. Expand
Disorders of Calcium, Phosphate, and Magnesium Metabolism
There have been substantial recent advances in the pathophysiology of calcium, phosphate, and magnesium disorders. These include the identification of novel transport pathways for magnesium,Expand
Childbirths and risk of female predominant and other autoimmune diseases in a population-based Danish cohort.
Pregnancies resulting in liveborn children seem to contribute only little to the general female predominance in autoimmune diseases; however, for a number of autoimmune diseases, erythema nodosum and sarcoidosis parity might somehow be involved in disease development. Expand
Dermatologic conditions in patients of color who are pregnant☆
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An Educational Resource StAtE of thE ARt PAPER on SARcoidoSiS provided by the thoracic Society of Australia and new Zealand
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Calcium metabolism in sarcoidosis and its clinical implications.
The mechanisms of abnormal calcium metabolism in sarcoidosis need to be understood when treating hypercalcaemia, hypercalcuria and corticosteroid-induced osteoporosis and studies are required to determine if the currently available therapies for osteopOrosis are safe and effective in sar coidosis. Expand
Different Mechanisms of Hypercalciuria in Sarcoidosis
Interest was stimulated by recent observations which disclosed high serum levels of 1,25-dihydroxyvitamin D, (1,25-(OH),-D,) in this disease and culminated when a coherent body of clinical and experimental data demonstrated that, in patients with sarcoidosis, the production of this dihydroxylated metabolite of vitamin D, can be e-trarenal. Expand
Calcium metabolism in sarcoidosis. A follow-up study with respect to parathyroid hormone and vitamin D metabolites.
The results of follow-up of untreated and treated patients support the suggestion that 1,25-(OH)2D may reflect the systemic granulomatous process (disease activity?) and the mechanism for abnormal calcium metabolism remains very complex and may not result from increased serum levels of 1, 25-(OH]2D alone. Expand
It is shown for the first time that hypercalcaemia in sarcoidosis is associated with abnormally high circulating concentrations of 1, 25-dihydroxycholecalciferol, probably as a result of overproduction of this, the hormonal form of vitamin D. Expand
Renal involvement in sarcoidosis
Histopathological changes specific of sarcoidosis are related to an abnormal amount of serum gammaglobulins and calciuria exceeding 200 mg in 24 hr, which seem to be the best tests of involvement by the disease. Expand
Parathyroid function in sarcoidosis.
The data indicate that most patients with sarcoidosis have functional hypoparathyroidism, which fits well with the recognized abnormalities of calcium metabolism in sarCOidosis, since excessiv... Expand
Sarcoidosis and pregnancy: a review with results of a retrospective survey
  • O. Selroos
  • Medicine
  • Journal of internal medicine
  • 1990
Pregnancy appears to have an ameliorating effect on sarcoidosis during the prenatal period, but that this benefit is frequently lost after delivery, and the available information indicates that for patients whose chest radiographic changes have changed. Expand
Calcium and phosphate metabolism in sarcoidosis with particular reference to parathyroid function.
Investigation of patients with sarcoidosis for abnormalities of calcium and phosphate metabolism with particular reference to parathyroid function found no abnormality of serum calcium, phosphate, creatinine or alkaline phosphatase, and serum levels of 25-OH cholecalciferol were normal. Expand
Ionized calcium and 1,25-dihydroxyvitamin D concentration in serum of patients with sarcoidosis.
A disease-related alteration in calcium metabolism was seen in about 40% of patients with sarcoidosis, and 1,25-dihydroxyvitamin D probably plays a crucial role in this abnormality. Expand
Sarcoidosis and pregnancy.
Cases of sarcoidosis and pregnancy during a ten-year period at Downstate Medical Center were reviewed, with factors indicating a poor prognosis included parenchymal lesions on chest x-ray, advanced roentgenologic staging, advanced maternal age, low inflammatory activity, requirement for drugs other than steroids, and presence of extrapulmonary sarcoIDosis. Expand